Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers: first clinical results using radiolabelled monoclonal antibodies against carcinoembryonic antigen.

Details

Serval ID
serval:BIB_AF7F23F6233F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers: first clinical results using radiolabelled monoclonal antibodies against carcinoembryonic antigen.
Journal
British Medical Journal
Author(s)
Berche C., Mach J.P., Lumbroso J.D., Langlais C., Aubry F., Buchegger F., Carrel S., Rougier P., Parmentier C., Tubiana M.
ISSN
0959-8138
0267-0623 (Print)
ISSN-L
0267-0623
Publication state
Published
Issued date
1982
Volume
285
Number
6353
Pages
1447-1451
Language
english
Abstract
Transaxial tomoscintigraphy (or single-photon emission computerised tomography) was used to detect secondary deposits of carcinoma in 17 patients who had been injected with iodine-131-labelled monoclonal antibodies against carcinoembryonic antigen. Of 17 tumor sites studied by tomoscintigraphy 16 were detected (sensitivity 94%); five sites had a volume smaller than 10 cm3. Tomoscintigraphy also detected three unknown tumour deposits later confirmed by surgery or radiology. In contrast, when 21 tumour sites in the same patients were studied by rectilinear scintigraphy, only nine tumour sites were detected (sensitivity 43%), of which eight had a volume larger than 50 cm3.
Keywords
Antibodies, Monoclonal/immunology, Carcinoembryonic Antigen/immunology, Gastrointestinal Neoplasms/radionuclide imaging, Gastrointestinal Neoplasms/secondary, Humans, Iodine Radioisotopes/diagnostic use, Thyroid Neoplasms/radionuclide imaging, Thyroid Neoplasms/secondary, Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:28
Last modification date
20/08/2019 16:18
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