Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus

Details

Serval ID
serval:BIB_AF37B6DBC381
Type
Article: article from journal or magazin.
Collection
Publications
Title
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Ruiz  J., Blanche  H., Cohen  N., Velho  G., Cambien  F., Cohen  D., Passa  P., Froguel  P.
ISSN
0027-8424
Publication state
Published
Issued date
04/1994
Volume
91
Number
9
Pages
3662-5
Notes
94224801
0027-8424
Journal Article --- Old month value: Apr 26 --- Old uritopublisher value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8170965
Abstract
Non-insulin-dependent diabetes mellitus (NIDDM) is considered a model of premature atherosclerosis with a strong genetic component. We have investigated the role of angiotensin-converting enzyme (ACE; EC 3.4.15.1) gene in 316 unrelated NIDDM individuals, 132 who had myocardial infarction or significant coronary stenoses and 184 with no history of coronary heart disease (CHD). A deletion-polymorphism in the ACE gene was recently reported to be associated with myocardial infarction especially in people classified as low risk. Here we report that the D allele of the ACE gene is a strong and independent risk factor for CHD in NIDDM patients. The D allele is associated with early-onset CHD in NIDDM, independently of hypertension and lipid values. A progressively increasing relative risk in individuals heterozygous and homozygous for the D allele was observed (odds ratios of 1.41 and 2.35, respectively; P < 0.007), suggesting a codominant effect on the cardiovascular risk. The percentage of CHD attributable to the ACE deletion allele was 24% in this NIDDM population. Identification of NIDDM patients carrying this putative CHD-susceptibility genotype would help early detection and treatment of CHD.
Keywords
Alleles Coronary Disease/*genetics Diabetes Mellitus, Non-Insulin-Dependent/*genetics Female Gene Deletion Gene Frequency Human Male Middle Age Peptidyl-Dipeptidase A/*genetics Regression Analysis Risk Factors Support, Non-U.S. Gov't
Pubmed
Web of science
Open Access
Yes
Create date
03/03/2008 15:16
Last modification date
20/08/2019 15:18
Usage data