Nosocomial outbreak of multiple bloodborne viral infections
Details
State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_AF212E1BAC29
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nosocomial outbreak of multiple bloodborne viral infections
Journal
Journal of Infectious Diseases
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
08/2001
Volume
184
Number
3
Pages
369-72
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Abstract
In resource-limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in approximately 400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission.
Keywords
Adult
*Blood-Borne Pathogens
Child
Cross Infection/*epidemiology
*Disease Outbreaks
Genotype
HIV Infections/blood/diagnosis/*epidemiology
HIV-1/classification/genetics/*isolation & purification
Hepacivirus/genetics/isolation & purification
Hepatitis B/blood/diagnosis/*epidemiology
Hepatitis B Antibodies/blood
Hepatitis C/blood/diagnosis/*epidemiology
Hepatitis C Antibodies/blood
Humans
Libya/epidemiology/ethnology
Parents
Phylogeny
RNA, Viral/blood/isolation & purification
Switzerland
Viremia/diagnosis/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:04
Last modification date
14/02/2022 8:56