Nosocomial outbreak of multiple bloodborne viral infections

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Serval ID
serval:BIB_AF212E1BAC29
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nosocomial outbreak of multiple bloodborne viral infections
Journal
Journal of Infectious Diseases
Author(s)
Yerly  S., Quadri  R., Negro  F., Barbe  K. P., Cheseaux  J. J., Burgisser  P., Siegrist  C. A., Perrin  L.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
08/2001
Volume
184
Number
3
Pages
369-72
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Abstract
In resource-limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in approximately 400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission.
Keywords
Adult *Blood-Borne Pathogens Child Cross Infection/*epidemiology *Disease Outbreaks Genotype HIV Infections/blood/diagnosis/*epidemiology HIV-1/classification/genetics/*isolation & purification Hepacivirus/genetics/isolation & purification Hepatitis B/blood/diagnosis/*epidemiology Hepatitis B Antibodies/blood Hepatitis C/blood/diagnosis/*epidemiology Hepatitis C Antibodies/blood Humans Libya/epidemiology/ethnology Parents Phylogeny RNA, Viral/blood/isolation & purification Switzerland Viremia/diagnosis/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:04
Last modification date
14/02/2022 7:56
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