Possible synergism of physical exercise and ghrelin-agonists in patients with cachexia associated with chronic heart failure.

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Serval ID
serval:BIB_AF10023A3978
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Possible synergism of physical exercise and ghrelin-agonists in patients with cachexia associated with chronic heart failure.
Journal
Aging clinical and experimental research
Author(s)
Invernizzi M., Carda S., Cisari C.
Working group(s)
Società Italiana per lo Studio della Sarcopenia e della Disabilità Muscolo-Scheletrica (SISDIM)
ISSN
1720-8319 (Electronic)
ISSN-L
1594-0667
Publication state
Published
Issued date
08/2014
Peer-reviewed
Oui
Volume
26
Number
4
Pages
341-351
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The occurrence of cachexia of multifactorial etiology in chronic heart failure (CHF) is a common and underestimated condition that usually leads to poor outcome and low survival rates, with high direct and indirect costs for the Health Care System. Recently, a consensus definition on cachexia has been reached, leading to a growing interest by the scientific community in this condition, which characterizes the last phase of many chronic diseases (i.e., cancer, acquired immunodeficiency syndrome). The etiology of cachexia is multifactorial and the underlying pathophysiological mechanisms are essentially the following: anorexia and malnourishment; immune overactivity and systemic inflammation; and endocrine disorders (anabolic/catabolic imbalance and resistance to growth hormone). In this paper, we review the main pathophysiological mechanisms underlying CHF cachexia, focusing also on the broad spectrum of actions of ghrelin and ghrelin agonists, and their possible use in combination with physical exercise to contrast CHF cachexia.
Keywords
Animals, Cachexia/drug therapy, Cachexia/etiology, Cachexia/pathology, Chronic Disease/drug therapy, Exercise/physiology, Ghrelin/agonists, Ghrelin/pharmacology, Heart Failure/complications, Heart Failure/pathology, Humans
Pubmed
Web of science
Create date
22/01/2015 19:14
Last modification date
23/10/2020 5:23
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