Article: article from journal or magazin.
Type I IFNs at the interface between cutaneous immunity and epidermal remodeling.
Journal of Investigative Dermatology
Publication types: Comment ; Journal Article Publication Status: ppublish
Type I IFNs are key cytokines in antiviral host defense. Preferentially expressed by plasmacytoid dendritic cells, type I IFNs are induced by viral infection and in common skin wounds. In this issue, Tohyama et al. identify a new link between type I IFNs and epidermal remodeling, by showing that type I IFNs specifically upregulate IL-22R expression on keratinocytes and, thereby, IL-22-mediated Stat3 phosphorylation in keratinocytes. The findings suggest that type I IFNs play dual roles in human skin: first, they induce immune activation with the induction of IL-22-producing T cells; second, they provide the interface between immune activation and epidermal remodeling by increasing keratinocyte responsiveness to IL-22.
Humans, Interferon-alpha/pharmacology, Keratinocytes/drug effects, Psoriasis/etiology, Receptors, Interleukin/genetics
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