CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients.

Détails

ID Serval
serval:BIB_AEDCAD0A39C3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients.
Périodique
Ajnr. American Journal of Neuroradiology
Auteur(s)
Meyer I.A., Wintermark M., Démonet J.F., Michel P.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
36
Numéro
10
Pages
1830-1833
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
BACKGROUND AND PURPOSE: Medial temporal lobe abnormalities on DWI and functional imaging are occasionally observed in patients with transient global amnesia. We used CTP to study these patients during or briefly after resolution of their amnesic syndrome.
MATERIALS AND METHODS: From 2002 onward, patients satisfying clinical criteria for transient global amnesia who underwent CTP were included. Patients with additional clinical features suggesting transient ischemic attack or stroke and those with an ischemic lesion on subsequent DWI were excluded. If deemed necessary by the clinician, DWI was performed within 10 days.
RESULTS: Thirty patients with transient global amnesia underwent CTP at a median latency of 5.9 hours (interquartile range, 4.3-9.7 hours) after symptom onset. All findings, except for those in 1 patient, were normal, including those in the 14 patients with well-imaged hippocampi. In the patient with abnormal findings, CTP and PWI showed hypoperfusion in both lentiform nuclei extending into the insulae, with normalization on the repeat CTP 6 days later. In 10 patients, DWI was performed at a median latency of 2 days (interquartile range, 0-9 days). Of these, 2 showed punctate hippocampal lesions, often seen in transient global amnesia. In 2 patients excluded because of mildly atypical transient global amnesia and ischemic lesions on subsequent DWI, acute CTP findings were also normal.
CONCLUSIONS: Patients with transient global amnesia had normal CTP findings in the acute phase with the exception of 1 patient with transient hypoperfusion in both basal ganglia. If imaging is performed for typical and atypical transient global amnesia, DWI should be the preferred method.
Mots-clé
Aged, Amnesia, Transient Global/diagnosis, Amnesia, Transient Global/pathology, Cytidine Triphosphate/metabolism, Diffusion Magnetic Resonance Imaging/methods, Dominance, Cerebral/physiology, Female, Hippocampus/pathology, Humans, Image Interpretation, Computer-Assisted, Ischemic Attack, Transient/diagnosis, Ischemic Attack, Transient/pathology, Male, Middle Aged, Stroke/diagnosis, Stroke/pathology, Temporal Lobe/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/11/2015 19:36
Dernière modification de la notice
08/05/2019 23:44
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