Prediction of ROP Treatment and Evaluation of Screening Criteria in VLBW Infants-a Population Based Analysis.
Details
Serval ID
serval:BIB_AECC54DF1BAF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prediction of ROP Treatment and Evaluation of Screening Criteria in VLBW Infants-a Population Based Analysis.
Journal
Pediatric research
Working group(s)
Swiss Neonatal Network & Follow-up Group
Contributor(s)
Anderegg C., Meyer P., Mori A.C., Kaeppeli D., Schulzke S., Weber P., Ramelli G.P., Nelle M., Wagner B., Steinlin M., Grunt S., Hassink R., Riedel T., Keller E., Killer C., Fuhrer K., Tolsa J.F., Roth-Kleiner M., Bickle-Graz M., Pfister R.E., Huppi P.S., Borradori-Tolsa C., Stocker M., Schmitt-Mechelke T., Bauder F., Pezzoli V., Erkert B., Mueller A., Ecoffey M., Malzacher A., Lang-Dullenkopf A., Micallef J.P., Hegi L., von Rhein M., Arlettaz R., Bassler D., Bernet V., Latal B., Natalucci G.
ISSN
1530-0447 (Electronic)
ISSN-L
0031-3998
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
84
Number
5
Pages
632-638
Language
english
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Publication Status: ppublish
Abstract
The incidence of retinopathy of prematurity (ROP) and ROP screening criteria differ between countries. We assessed whether ROP screening could be reduced based on the local ROP incidence.
Observational cohort study of infants born in Switzerland between 2006 and 2015 <32 0/7 weeks. Chronological and postmenstrual ages at ROP treatment were analyzed. A model to identify ROP treatment on patients born between 2006 and 2012 (training set) was developed and tested on patients born between 2013 and 2015 (validation set).
Of 7817 live-born infants, 1098 died within the first 5 weeks of life. The remaining 6719 infants were included into analysis. All patients requiring ROP treatment would have been identified if screening had been performed before reaching 60 days of life or 37 3/7 weeks postmenstrual age, whichever came first. The training and validation sets included 4522 and 2197 preterm infants encompassing 56 and 20 patients receiving ROP treatment, respectively. All patients would have required screening to reach 100% sensitivity. To reach a sensitivity of 95.0% and a specificity of 87.6%, we predicted a reduction in 13.2% of patients requiring screening (c-statistic = 0.916).
A substantial reduction of infants requiring screening seems possible, but necessitates prospective testing of new screening criteria.
Observational cohort study of infants born in Switzerland between 2006 and 2015 <32 0/7 weeks. Chronological and postmenstrual ages at ROP treatment were analyzed. A model to identify ROP treatment on patients born between 2006 and 2012 (training set) was developed and tested on patients born between 2013 and 2015 (validation set).
Of 7817 live-born infants, 1098 died within the first 5 weeks of life. The remaining 6719 infants were included into analysis. All patients requiring ROP treatment would have been identified if screening had been performed before reaching 60 days of life or 37 3/7 weeks postmenstrual age, whichever came first. The training and validation sets included 4522 and 2197 preterm infants encompassing 56 and 20 patients receiving ROP treatment, respectively. All patients would have required screening to reach 100% sensitivity. To reach a sensitivity of 95.0% and a specificity of 87.6%, we predicted a reduction in 13.2% of patients requiring screening (c-statistic = 0.916).
A substantial reduction of infants requiring screening seems possible, but necessitates prospective testing of new screening criteria.
Keywords
Humans, Incidence, Infant, Newborn, Infant, Very Low Birth Weight, Male, Population Surveillance, Retinopathy of Prematurity/diagnosis, Retinopathy of Prematurity/epidemiology, Retinopathy of Prematurity/therapy, Retrospective Studies, Sensitivity and Specificity, Switzerland/epidemiology
Pubmed
Web of science
Create date
02/10/2019 20:16
Last modification date
16/07/2020 8:43
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