Article: article from journal or magazin.
Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae.
BACKGROUND: The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main objective of this study was to determine a treatment modality impeding the emergence of quinolone resistance. RESULTS: Exposure of a penicillin-resistant pneumococcus to increasing concentrations of trovafloxacin or ciprofloxacin selected for mutants resistant to these drugs. In the presence of sub-inhibitory concentrations of vancomycin, development of trovafloxacin-resistance and high-level ciprofloxacin-resistance were prevented. CONCLUSIONS: Considering the risk of quinolone-resistance in pneumococci, the observation might be of clinical importance.
4-Quinolones, Anti-Bacterial Agents/pharmacology, Anti-Infective Agents/pharmacology, Drug Interactions, Drug Resistance, Bacterial/physiology, Microbial Sensitivity Tests, Penicillin Resistance/physiology, Streptococcus pneumoniae/drug effects, Vancomycin/pharmacology
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