Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Fox, E.R.; Young, J.H.; Li, Y.; Dreisbach, A.W.; Keating, B.J.; Musani, S.K.; Liu, K.; Morrison, A.C.; Ganesh, S.; Kutlar, A.; Ramachandran, V.S.; Polak, J.F.; Fabsitz, R.R.; Dries, D.L.; Farlow, D.N.; Redline, S.; Adeyemo, A.; Hirschorn, J.N.; Sun, Y.V.; Wyatt, S.B.; Penman, A.D.; Palmas, W.; Rotter, J.I.; Townsend, R.R.; Doumatey, A.P.; Tayo, B.O.; Mosley, T.H.; Lyon, H.N.; Kang, S.J.; Rotimi, C.N.; Cooper, R.S.; Franceschini, N.; Curb, J.D.; Martin, L.W.; Eaton, C.B.; Kardia, S.L.; Taylor, H.A.; Caulfield, M.J.; Ehret, G.B.; Johnson, T.; Chakravarti, A.; Chakravarti, A.; Zhu, X.; Levy, D.; Munroe, P.B.; Rice, K.M.; Bochud, M.; Johnson, A.D.; Chasman, D.I.; Smith, A.V.; Tobin, M.D.; Verwoert, G.C.; Hwang, S.J.; Pihur, V.; Vollenweider, P.; O'Reilly, P.F.; Amin, N.; Bragg-Gresham, J.L.; Teumer, A.; Glazer, N.L.; Launer, L.; Zhao, J.H.; Aulchenko, Y.; Heath, S.; Sõber, S.; Parsa, A.; Luan, J.; Arora, P.; Dehghan, A.; Zhang, F.; Lucas, G.; Hicks, A.A.; Jackson, A.U.; Peden, J.F.; Tanaka, T.; Wild, S.H.; Rudan, I.; Igl, W.; Milaneschi, Y.; Parker, A.N.; Fava, C.; Chambers, J.C.; Kumari, M.; Go, M.J.; van der Harst, P.; Kao, W.H.; Sjögren, M.; Vinay, D.G.; Alexander, M.; Tabara, Y.; Shaw-Hawkins, S.; Whincup, P.H.; Liu, Y.; Shi, G.; Kuusisto, J.; Seielstad, M.; Sim, X.; Nguyen, K.D.; Lehtimäki, T.; Matullo, G.; Wu, Y.; Gaunt, T.R.; Onland-Moret, N.C.; Cooper, M.N.; Platou, C.G.; Org, E.; Hardy, R.; Dahgam, S.; Palmen, J.; Vitart, V.; Braund, P.S.; Kuznetsova, T.; Uiterwaal, C.S.; Campbell, H.; Ludwig, B.; Tomaszewski, M.; Tzoulaki, I.; Palmer, N.D.; Aspelund, T.; Aspelund, T.; Garcia, M.; Chang, Y.P.; O'Connell, J.R.; Steinle, N.I.; Grobbee, D.E.; Arking, D.E.; Hernandez, D.; Najjar, S.; McArdle, W.L.; Hadley, D.; Brown, M.J.; Connell, J.M.; Hingorani, A.D.; Day, I.N.; Lawlor, D.A.; Beilby, J.P.; Lawrence, R.W.; Clarke, R.; Collins, R.; Hopewell, J.C.; Ongen, H.; Bis, J.C.; Kähönen, M.; Viikari, J.; Adair, L.S.; Lee, N.R.; Chen, M.H.; Olden, M.; Pattaro, C.; Hoffman Bolton, J.A.; Köttgen, A.; Bergmann, S.; Mooser, V.; Chaturvedi, N.; Frayling, T.M.; Islam, M.; Jafar, T.H.; Erdmann, J.; Kulkarni, S.R.; Bornstein, S.R.; Grässler, J.; Groop, L.; Voight, B.F.; Kettunen, J.; Howard, P.; Taylor, A.; Guarrera, S.; Ricceri, F.; Emilsson, V.; Plump, A.; Barroso, I.; Khaw, K.T.; Weder, A.B.; Hunt, S.C.; Bergman, R.N.; Collins, F.S.; Bonnycastle, L.L.; Scott, L.J.; Stringham, H.M.; Peltonen, L.; Perola, M.; Vartiainen, E.; Brand, S.M.; Staessen, J.A.; Wang, T.J.; Burton, P.R.; Artigas, M.S.; Dong, Y.; Snieder, H.; Wang, X.; Zhu, H.; Lohman, K.K.; Rudock, M.E.; Heckbert, S.R.; Smith, N.L.; Wiggins, K.L.; Shriner, D.; Veldre, G.; Viigimaa, M.; Kinra, S.; Prabhakaran, D.; Tripathy, V.; Langefeld, C.D.; Rosengren, A.; Thelle, D.S.; Corsi, A.M.; Singleton, A.; Forrester, T.; Hilton, G.; McKenzie, C.A.; Salako, T.; Iwai, N.; Kita, Y.; Ogihara, T.; Ohkubo, T.; Okamura, T.; Ueshima, H.; Umemura, S.; Eyheramendy, S.; Meitinger, T.; Wichmann, H.E.; Cho, Y.S.; Kim, H.L.; Lee, J.Y.; Scott, J.; Sehmi, J.S.; Zhang, W.; Hedblad, B.; Nilsson, P.; Smith, G.D.; Wong, A.; Narisu, N.; Stancáková, A.; Raffel, L.J.; Yao, J.; Kathiresan, S.; O'Donnell, C.; Schwartz, S.M.; Ikram, M.A.; Longstreth, W.T.; Seshadri, S.; Shrine, N.R.; Wain, L.V.; Morken, M.A.; Swift, A.J.; Laitinen, J.; Prokopenko, I.; Zitting, P.; Cooper, J.A.; Humphries, S.E.; Danesh, J.; Rasheed, A.; Goel, A.; Hamsten, A.; Watkins, H.; Bakker, S.J.; van Gilst, W.H.; Janipalli, C.; Mani, K.R.; Yajnik, C.S.; Hofman, A.; Mattace-Raso, F.U.; Oostra, B.A.; Demirkan, A.; Isaacs, A.; Rivadeneira, F.; Lakatta, E.G.; Orru, M.; Scuteri, A.; Ala-Korpela, M.; Kangas, A.J.; Lyytikäinen, L.P.; Soininen, P.; Tukiainen, T.; Würz, P.; Ong, R.T.; Dörr, M.; Kroemer, H.K.; Völker, U.; Völzke, H.; Galan, P.; Hercberg, S.; Lathrop, M.; Zelenika, D.; Deloukas, P.; Mangino, M.; Spector, T.D.; Zhai, G.; Meschia, J.F.; Nalls, M.A.; Sharma, P.; Terzic, J.; Kumar, M.J.; Denniff, M.; Zukowska-Szczechowska, E.; Wagenknecht, L.E.; Fowkes, F.G.; Charchar, F.J.; Schwarz, P.E.; Hayward, C.; Guo, X.; Bots, M.L.; Brand, E.; Samani, N.; Polasek, O.; Talmud, P.J.; Nyberg, F.; Kuh, D.; Laan, M.; Hveem, K.; Palmer, L.J.; van der Schouw, Y.T.; Casas, J.P.; Mohlke, K.L.; Vineis, P.; Raitakari, O.; Wong, T.Y.; Tai, E.S.; Laakso, M.; Rao, D.C.; Harris, T.B.; Morris, R.W.; Dominiczak, A.F.; Kivimaki, M.; Marmot, M.G.; Miki, T.; Saleheen, D.; Chandak, G.R.; Coresh, J.; Navis, G.; Salomaa, V.; Han, B.G.; Kooner, J.S.; Melander, O.; Ridker, P.M.; Bandinelli, S.; Gyllensten, U.B.; Wright, A.F.; Wilson, J.F.; Ferrucci, L.; Farrall, M.; Tuomilehto, J.; Pramstaller, P.P.; Elosua, R.; Soranzo, N.; Sijbrands, E.J.; Altshuler, D.; Loos, R.J.; Shuldiner, A.R.; Gieger, C.; Meneton, P.; Uitterlinden, A.G.; Wareham, N.J.; Gudnason, V.; Rettig, R.; Uda, M.; Strachan, D.P.; Witteman, J.C.; Hartikainen, A.L.; Beckmann, J.S.; Boerwinkle, E.; Boehnke, M.; Larson, M.G.; Järvelin, M.R.; Psaty, B.M.; Abecasis, G.R.; Elliott, P.; van Duijn, C.M.; Newton-Cheh, C.

doi:10.1093/hmg/ddr092

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Details

Download: BIB_AE8CBFCBEF3C.P001.pdf (209.74 [Ko])
State: Public
Version: Final published version

Serval ID

serval:BIB_AE8CBFCBEF3C

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Journal

Human Molecular Genetics

Author(s)

Fox E.R., Young J.H., Li Y., Dreisbach A.W., Keating B.J., Musani S.K., Liu K., Morrison A.C., Ganesh S., Kutlar A., Ramachandran V.S., Polak J.F., Fabsitz R.R., Dries D.L., Farlow D.N., Redline S., Adeyemo A., Hirschorn J.N., Sun Y.V., Wyatt S.B., Penman A.D., Palmas W., Rotter J.I., Townsend R.R., Doumatey A.P., Tayo B.O., Mosley T.H., Lyon H.N., Kang S.J., Rotimi C.N., Cooper R.S., Franceschini N., Curb J.D., Martin L.W., Eaton C.B., Kardia S.L., Taylor H.A., Caulfield M.J., Ehret G.B., Johnson T., Chakravarti A., Chakravarti A., Zhu X., Levy D., Munroe P.B., Rice K.M., Bochud M., Johnson A.D., Chasman D.I., Smith A.V., Tobin M.D., Verwoert G.C., Hwang S.J., Pihur V., Vollenweider P., O'Reilly P.F., Amin N., Bragg-Gresham J.L., Teumer A., Glazer N.L., Launer L., Zhao J.H., Aulchenko Y., Heath S., Sõber S., Parsa A., Luan J., Arora P., Dehghan A., Zhang F., Lucas G., Hicks A.A., Jackson A.U., Peden J.F., Tanaka T., Wild S.H., Rudan I., Igl W., Milaneschi Y., Parker A.N., Fava C., Chambers J.C., Kumari M., Go M.J., van der Harst P., Kao W.H., Sjögren M., Vinay D.G., Alexander M., Tabara Y., Shaw-Hawkins S., Whincup P.H., Liu Y., Shi G., Kuusisto J., Seielstad M., Sim X., Nguyen K.D., Lehtimäki T., Matullo G., Wu Y., Gaunt T.R., Onland-Moret N.C., Cooper M.N., Platou C.G., Org E., Hardy R., Dahgam S., Palmen J., Vitart V., Braund P.S., Kuznetsova T., Uiterwaal C.S., Campbell H., Ludwig B., Tomaszewski M., Tzoulaki I., Palmer N.D., Aspelund T., Aspelund T., Garcia M., Chang Y.P., O'Connell J.R., Steinle N.I., Grobbee D.E., Arking D.E., Hernandez D., Najjar S., McArdle W.L., Hadley D., Brown M.J., Connell J.M., Hingorani A.D., Day I.N., Lawlor D.A., Beilby J.P., Lawrence R.W., Clarke R., Collins R., Hopewell J.C., Ongen H., Bis J.C., Kähönen M., Viikari J., Adair L.S., Lee N.R., Chen M.H., Olden M., Pattaro C., Hoffman Bolton J.A., Köttgen A., Bergmann S., Mooser V., Chaturvedi N., Frayling T.M., Islam M., Jafar T.H., Erdmann J., Kulkarni S.R., Bornstein S.R., Grässler J., Groop L., Voight B.F., Kettunen J., Howard P., Taylor A., Guarrera S., Ricceri F., Emilsson V., Plump A., Barroso I., Khaw K.T., Weder A.B., Hunt S.C., Bergman R.N., Collins F.S., Bonnycastle L.L., Scott L.J., Stringham H.M., Peltonen L., Perola M., Vartiainen E., Brand S.M., Staessen J.A., Wang T.J., Burton P.R., Artigas M.S., Dong Y., Snieder H., Wang X., Zhu H., Lohman K.K., Rudock M.E., Heckbert S.R., Smith N.L., Wiggins K.L., Shriner D., Veldre G., Viigimaa M., Kinra S., Prabhakaran D., Tripathy V., Langefeld C.D., Rosengren A., Thelle D.S., Corsi A.M., Singleton A., Forrester T., Hilton G., McKenzie C.A., Salako T., Iwai N., Kita Y., Ogihara T., Ohkubo T., Okamura T., Ueshima H., Umemura S., Eyheramendy S., Meitinger T., Wichmann H.E., Cho Y.S., Kim H.L., Lee J.Y., Scott J., Sehmi J.S., Zhang W., Hedblad B., Nilsson P., Smith G.D., Wong A., Narisu N., Stancáková A., Raffel L.J., Yao J., Kathiresan S., O'Donnell C., Schwartz S.M., Ikram M.A., Longstreth W.T., Seshadri S., Shrine N.R., Wain L.V., Morken M.A., Swift A.J., Laitinen J., Prokopenko I., Zitting P., Cooper J.A., Humphries S.E., Danesh J., Rasheed A., Goel A., Hamsten A., Watkins H., Bakker S.J., van Gilst W.H., Janipalli C., Mani K.R., Yajnik C.S., Hofman A., Mattace-Raso F.U., Oostra B.A., Demirkan A., Isaacs A., Rivadeneira F., Lakatta E.G., Orru M., Scuteri A., Ala-Korpela M., Kangas A.J., Lyytikäinen L.P., Soininen P., Tukiainen T., Würz P., Ong R.T., Dörr M., Kroemer H.K., Völker U., Völzke H., Galan P., Hercberg S., Lathrop M., Zelenika D., Deloukas P., Mangino M., Spector T.D., Zhai G., Meschia J.F., Nalls M.A., Sharma P., Terzic J., Kumar M.J., Denniff M., Zukowska-Szczechowska E., Wagenknecht L.E., Fowkes F.G., Charchar F.J., Schwarz P.E., Hayward C., Guo X., Bots M.L., Brand E., Samani N., Polasek O., Talmud P.J., Nyberg F., Kuh D., Laan M., Hveem K., Palmer L.J., van der Schouw Y.T., Casas J.P., Mohlke K.L., Vineis P., Raitakari O., Wong T.Y., Tai E.S., Laakso M., Rao D.C., Harris T.B., Morris R.W., Dominiczak A.F., Kivimaki M., Marmot M.G., Miki T., Saleheen D., Chandak G.R., Coresh J., Navis G., Salomaa V., Han B.G., Kooner J.S., Melander O., Ridker P.M., Bandinelli S., Gyllensten U.B., Wright A.F., Wilson J.F., Ferrucci L., Farrall M., Tuomilehto J., Pramstaller P.P., Elosua R., Soranzo N., Sijbrands E.J., Altshuler D., Loos R.J., Shuldiner A.R., Gieger C., Meneton P., Uitterlinden A.G., Wareham N.J., Gudnason V., Rettig R., Uda M., Strachan D.P., Witteman J.C., Hartikainen A.L., Beckmann J.S., Boerwinkle E., Boehnke M., Larson M.G., Järvelin M.R., Psaty B.M., Abecasis G.R., Elliott P., van Duijn C.M., Newton-Cheh C.

Working group(s)

International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), CARDIoGRAM consortium, CKDGen consortium, KidneyGen consortium, EchoGen consortium, CHARGE-HF consortium

ISSN

1460-2083 (Electronic)

ISSN-L

0964-6906

Publication state

Published

Issued date

2011

Peer-reviewed

Oui

Volume

Number

Pages

2273-2284

Language

english

Abstract

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.

Keywords

Adult, African Americans/genetics, Aged, Blood Pressure, Cohort Studies, Diastole, European Continental Ancestry Group/genetics, Female, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Hypertension/epidemiology, Hypertension/genetics, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Systole

URN

urn:nbn:ch:serval-BIB_AE8CBFCBEF3C3

OAI-PMH

oai:serval.unil.ch:BIB_AE8CBFCBEF3C

DOI

10.1093/hmg/ddr092

Pubmed

21378095

Web of science

000290589800017

Open Access

Yes