EXTRAMACULAR FIBROSIS IN COATS' DISEASE.

Détails

ID Serval
serval:BIB_AE473D2B857E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
EXTRAMACULAR FIBROSIS IN COATS' DISEASE.
Périodique
Retina (Philadelphia, Pa.)
Auteur(s)
Daruich A., Matet A., Tran H.V., Gaillard M.C., Munier F.L.
ISSN
1539-2864 (Electronic)
ISSN-L
0275-004X
Statut éditorial
Publié
Date de publication
04/2016
Peer-reviewed
Oui
Volume
36
Numéro
10
Pages
2022-2028
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
To determine the rate, risk factors, and outcome of extramacular fibrosis in Coats' disease.
Consecutive cases from a single center were retrospectively reviewed. Clinical characteristics and treatments were analyzed by comparative, multivariate, and survival approaches.
Among 69 patients with Coats' disease, 28 (40.6%) showed evidence of extramacular fibrosis (mean follow-up: 58.2 months). Mean time of fibrosis onset was 17.4 months. Extent of retinal exudation and rate of exudative retinal detachment at baseline were significantly higher in eyes that developed extramacular fibrosis compared with those that did not (P < 0.001). Similarly, these parameters showed significant differences using multivariate (P < 0.05) and survival analysis (P < 0.001). Extension of telangiectasia, number of cryotherapy, or laser sessions, and treatment by anti-vascular endothelial growth factor were not associated with extramacular fibrosis. Final visual acuity was worse in patients with extramacular fibrosis (P < 0.001). The rates of tractional retinal detachment and macular fibrosis were higher in patients with extramacular fibrosis (39%.0 vs. 0% and 60.7% vs. 19.5%, respectively, P < 0.001).
Extramacular fibrosis led to a worse visual prognosis and was associated with the extension of retinal exudation and the presence of exudative retinal detachment at diagnosis. Treatment should target a quick resolution of exudation to limit its development.

Mots-clé
Adolescent, Adult, Angiogenesis Inhibitors/therapeutic use, Case-Control Studies, Child, Child, Preschool, Cryotherapy, Female, Fibrosis/etiology, Fluorescein Angiography, Humans, Infant, Laser Coagulation, Male, Retina/pathology, Retinal Detachment/etiology, Retinal Detachment/physiopathology, Retinal Telangiectasis/complications, Retinal Telangiectasis/diagnosis, Retinal Telangiectasis/physiopathology, Retinal Telangiectasis/therapy, Retrospective Studies, Risk Factors, Visual Acuity/physiology, Vitreous Body/pathology
Pubmed
Création de la notice
16/02/2016 17:51
Dernière modification de la notice
20/08/2019 15:18
Données d'usage