The expansion of amino-acid repeats is not associated to adaptive evolution in mammalian genes.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_AE3C1C5E6707
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The expansion of amino-acid repeats is not associated to adaptive evolution in mammalian genes.
Périodique
BMC Genomics
Auteur(s)
Cruz F., Roux J., Robinson-Rechavi M.
ISSN
1471-2164[electronic], 1471-2164[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
10
Numéro
1
Pages
619
Langue
anglais
Résumé
BACKGROUND: The expansion of amino acid repeats is determined by a high mutation rate and can be increased or limited by selection. It has been suggested that recent expansions could be associated with the potential of adaptation to new environments. In this work, we quantify the strength of this association, as well as the contribution of potential confounding factors. RESULTS: Mammalian positively selected genes have accumulated more recent amino acid repeats than other mammalian genes. However, we found little support for an accelerated evolutionary rate as the main driver for the expansion of amino acid repeats. The most significant predictors of amino acid repeats are gene function and GC content. There is no correlation with expression level. CONCLUSIONS: Our analyses show that amino acid repeat expansions are causally independent from protein adaptive evolution in mammalian genomes. Relaxed purifying selection or positive selection do not associate with more or more recent amino acid repeats. Their occurrence is slightly favoured by the sequence context but mainly determined by the molecular function of the gene.
Mots-clé
Animals, Base Composition, Comparative Genomic Hybridization, Evolution, Molecular, Gene Expression Profiling, Genome, Mammals/genetics, Models, Genetic, Repetitive Sequences, Amino Acid/genetics, Selection, Genetic, Sequence Alignment
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/12/2009 16:58
Dernière modification de la notice
20/08/2019 15:18
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