An Essential Role for Insulin and IGF1 Receptors in Regulating Sertoli Cell Proliferation, Testis Size, and FSH Action in Mice.

Details

Serval ID
serval:BIB_AE007020D8CC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
An Essential Role for Insulin and IGF1 Receptors in Regulating Sertoli Cell Proliferation, Testis Size, and FSH Action in Mice.
Journal
Molecular Endocrinology
Author(s)
Pitetti J.L., Calvel P., Zimmermann C., Conne B., Papaioannou M.D., Aubry F., Cederroth C.R., Urner F., Fumel B., Crausaz M., Docquier M., Herrera P.L., Pralong F., Germond M., Guillou F., Jégou B., Nef S.
ISSN
1944-9917 (Electronic)
ISSN-L
0888-8809
Publication state
Published
Issued date
2013
Volume
27
Number
5
Pages
814-827
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Original research
Abstract
Testis size and sperm production are directly correlated to the total number of adult Sertoli cells (SCs). Although the establishment of an adequate number of SCs is crucial for future male fertility, the identification and characterization of the factors regulating SC survival, proliferation, and maturation remain incomplete. To investigate whether the IGF system is required for germ cell (GC) and SC development and function, we inactivated the insulin receptor (Insr), the IGF1 receptor (Igf1r), or both receptors specifically in the GC lineage or in SCs. Whereas ablation of insulin/IGF signaling appears dispensable for GCs and spermatogenesis, adult testes of mice lacking both Insr and Igf1r in SCs (SC-Insr;Igf1r) displayed a 75% reduction in testis size and daily sperm production as a result of a reduced proliferation rate of immature SCs during the late fetal and early neonatal testicular period. In addition, in vivo analyses revealed that FSH requires the insulin/IGF signaling pathway to mediate its proliferative effects on immature SCs. Collectively, these results emphasize the essential role played by growth factors of the insulin family in regulating the final number of SCs, testis size, and daily sperm output. They also indicate that the insulin/IGF signaling pathway is required for FSH-mediated SC proliferation.
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2013 16:26
Last modification date
20/08/2019 15:17
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