Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease.

Details

Serval ID
serval:BIB_ADF803A90E1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease.
Journal
Clinical science
Author(s)
Leporq B., Daire J.L., Pastor C.M., Deltenre P., Sempoux C., Schmidt S., Van Beers B.E.
ISSN
1470-8736 (Electronic)
ISSN-L
0143-5221
Publication state
Published
Issued date
16/04/2018
Peer-reviewed
Oui
Volume
132
Number
7
Pages
813-824
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The purpose of the present study was to develop and perform initial validation of dynamic MRI enhanced with gadoxetic acid as hepatobiliary contrast agent to quantify hepatic perfusion and hepatocyte function in patients with chronic liver disease. Free-breathing, dynamic gadoxetic acid-enhanced MRI was performed at 3.0 T using a 3D time-resolved angiography sequence with stochastic trajectories during 38 min. A dual-input three-compartment model was developed to derive hepatic perfusion and hepatocyte function parameters. Method feasibility was assessed in 23 patients with biopsy-proven chronic liver disease. Parameter analysis could be performed in 21 patients (91%). The hepatocyte function parameters were more discriminant than the perfusion parameters to differentiate between patients with minimal fibrosis (METAVIR F0-F1), intermediate fibrosis (F2-F3) and cirrhosis (F4). The areas under the receiver operating characteristic curves (ROCs) to diagnose significant fibrosis (METAVIR F ≥ 2) were: 0.95 (95% CI: 0.87-1; P<0.001) for biliary efflux, 0.88 (95% CI: 0.73-1; P<0.01) for sinusoidal backflux, 0.81 (95% CI: 0.61-1; P<0.05) for hepatocyte uptake fraction and 0.75 (95% CI: 0.54-1; P<0.05) for hepatic perfusion index (HPI), respectively. These initial results in patients with chronic liver diseases show that simultaneous quantification of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI. Hepatocyte function parameters may be relevant to assess liver fibrosis severity.
Keywords
Adult, Aged, Contrast Media, Female, Gadolinium DTPA, Hepatic Insufficiency/diagnostic imaging, Hepatocytes/physiology, Humans, Liver Circulation, Magnetic Resonance Imaging/methods, Male, Middle Aged, Prospective Studies, Gadoxetic acid, Hepatic function, Hepatic perfusion, Liver fibrosis, MRI
Pubmed
Web of science
Create date
15/02/2018 17:43
Last modification date
20/08/2019 15:17
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