Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.

Détails

Ressource 1Télécharger: 1-s2.0-S2211124716301279-main.pdf (8853.39 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_AD9469DE8B52
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.
Périodique
Cell Reports
Auteur(s)
Chen F., Zhang Y., Şenbabaoğlu Y., Ciriello G., Yang L., Reznik E., Shuch B., Micevic G., De Velasco G., Shinbrot E., Noble M.S., Lu Y., Covington K.R., Xi L., Drummond J.A., Muzny D., Kang H., Lee J., Tamboli P., Reuter V., Shelley C.S., Kaipparettu B.A., Bottaro D.P., Godwin A.K., Gibbs R.A., Getz G., Kucherlapati R., Park P.J., Sander C., Henske E.P., Zhou J.H., Kwiatkowski D.J., Ho T.H., Choueiri T.K., Hsieh J.J., Akbani R., Mills G.B., Hakimi A.A., Wheeler D.A., Creighton C.J.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
14
Numéro
10
Pages
2476-2489
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset.
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/10/2016 10:54
Dernière modification de la notice
20/08/2019 15:17
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