Article: article from journal or magazin.
Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers.
Journal of cardiovascular pharmacology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Synthetic atrial natriuretic peptide, containing 26 amino acids in the rat sequence, L-364, 343 (Ileu-ANP), was infused intravenously at increasing rates (1-40 micrograms/min) into four normal volunteers. Mean intraarterial blood pressure decreased and heart rate increased in cumulative-dose-dependent fashion. Skin blood flow as measured with a laser Doppler device rose already with a cumulative dose of 55 micrograms Ileu-ANP and further rises were directly related to dose. The only side effects observed were those accompanying symptomatic hypotension at higher doses. These findings provide strong evidence that Ileu-ANP acts as a vasodilator in normal volunteers.
Adult, Atrial Natriuretic Factor, Blood Pressure, Heart Rate, Hemodynamics, Humans, Infusions, Parenteral, Male, Peptide Fragments, Regional Blood Flow, Skin
Web of science
Last modification date