Article: article from journal or magazin.
A comparison of in vivo 13C MR brain glycogen quantification at 9.4 and 14.1 T.
Magnetic Resonance in Medicine
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The high molecular weight and low concentration of brain glycogen render its noninvasive quantification challenging. Therefore, the precision increase of the quantification by localized (13) C MR at 9.4 to 14.1 T was investigated. Signal-to-noise ratio increased by 66%, slightly offset by a T(1) increase of 332 ± 15 to 521 ± 34 ms. Isotopic enrichment after long-term (13) C administration was comparable (≈ 40%) as was the nominal linewidth of glycogen C1 (≈ 50 Hz). Among the factors that contributed to the 66% observed increase in signal-to-noise ratio, the T(1) relaxation time impacted the effective signal-to-noise ratio by only 10% at a repetition time = 1 s. The signal-to-noise ratio increase together with the larger spectral dispersion at 14.1 T resulted in a better defined baseline, which allowed for more accurate fitting. Quantified glycogen concentrations were 5.8 ± 0.9 mM at 9.4 T and 6.0 ± 0.4 mM at 14.1 T; the decreased standard deviation demonstrates the compounded effect of increased magnetization and improved baseline on the precision of glycogen quantification.
Algorithms, Animals, Brain/anatomy & histology, Brain/metabolism, Carbon Isotopes/analysis, Carbon Isotopes/diagnostic use, Glycogen/analysis, Image Enhancement/methods, Image Interpretation, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Magnetic Resonance Spectroscopy/methods, Male, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity
Web of science
Last modification date