Cytosine methylation flags mitochondrial RNA for degradation.

Recazens, E.; Jourdain, A.A.

doi:10.1016/j.tibs.2024.08.001

Cytosine methylation flags mitochondrial RNA for degradation.

Details

Download: recazens-jourdain_tibs.pdf (517.62 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_AC4B4D2C8B5F

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Cytosine methylation flags mitochondrial RNA for degradation.

Journal

Trends in biochemical sciences

Author(s)

Recazens E., Jourdain A.A.

ISSN

0968-0004 (Print)

ISSN-L

0968-0004

Publication state

Published

Issued date

10/2024

Peer-reviewed

Oui

Volume

Number

Pages

843-845

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

Mitochondrial double-stranded RNA (dsRNA) can form spontaneously in mitochondria, blocking mitochondrial gene expression and triggering an immune response. A recent study by Kim, Tan, et al. identified a safeguard mechanism in which NOP2/Sun RNA methyltransferase 4 (NSUN4)-mediated RNA methylation (m <sup>5</sup> C) recruits the RNA degradation machinery to prevent dsRNA formation.

Keywords

RNA, Mitochondrial/metabolism, Humans, Methylation, Cytosine/metabolism, Mitochondria/metabolism, RNA Stability, RNA/metabolism, RNA, Double-Stranded/metabolism, Methyltransferases/metabolism, Animals, 5-methylcytosine, RNA degradation, dsRNA, immunity, mitochondrial RNA, nucleic acid sensing

URN

urn:nbn:ch:serval-BIB_AC4B4D2C8B5F8

OAI-PMH

oai:serval.unil.ch:BIB_AC4B4D2C8B5F

DOI

10.1016/j.tibs.2024.08.001

Pubmed

39181838

Open Access

Yes

Create date

30/08/2024 15:18