Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.

Details

Serval ID
serval:BIB_AC141FEAEB62
Type
Article: article from journal or magazin.
Collection
Publications
Title
Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.
Journal
Schizophrenia bulletin
Author(s)
Klauser P., Zhou J., Lim J.K., Poh J.S., Zheng H., Tng H.Y., Krishnan R., Lee J., Keefe R.S., Adcock R.A., Wood S.J., Fornito A., Chee M.W.
ISSN
1745-1701 (Electronic)
ISSN-L
0586-7614
Publication state
Published
Issued date
11/2015
Peer-reviewed
Oui
Volume
41
Number
6
Pages
1285-1293
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
There is cumulative evidence that young people in an "at-risk mental state" (ARMS) for psychosis show structural brain abnormalities in frontolimbic areas, comparable to, but less extensive than those reported in established schizophrenia. However, most available data come from ARMS samples from Australia, Europe, and North America while large studies from other populations are missing. We conducted a structural brain magnetic resonance imaging study from a relatively large sample of 69 ARMS individuals and 32 matched healthy controls (HC) recruited from Singapore as part of the Longitudinal Youth At-Risk Study (LYRIKS). We used 2 complementary approaches: a voxel-based morphometry and a surface-based morphometry analysis to extract regional gray and white matter volumes (GMV and WMV) and cortical thickness (CT). At the whole-brain level, we did not find any statistically significant difference between ARMS and HC groups concerning total GMV and WMV or regional GMV, WMV, and CT. The additional comparison of 2 regions of interest, hippocampal, and ventricular volumes, did not return any significant difference either. Several characteristics of the LYRIKS sample like Asian origins or the absence of current illicit drug use could explain, alone or in conjunction, the negative findings and suggest that there may be no dramatic volumetric or CT abnormalities in ARMS.
Keywords
Adolescent, Adult, Cerebral Cortex/pathology, Female, Gray Matter/pathology, Humans, Magnetic Resonance Imaging, Male, Psychotic Disorders/pathology, Risk, Singapore, White Matter/pathology, Young Adult, early psychosis, magnetic resonance imaging, schizophrenia, surface-based morphometry, voxel-based morphometry
Pubmed
Web of science
Open Access
Yes
Create date
07/02/2019 9:24
Last modification date
02/09/2019 5:26
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