Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability.

Details

Serval ID
serval:BIB_AB7F94C3851A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability.
Journal
Molecular and cellular neurosciences
Author(s)
De Rubeis S., Bagni C.
ISSN
1095-9327 (Electronic)
ISSN-L
1044-7431
Publication state
Published
Issued date
01/2010
Volume
43
Number
1
Pages
43-50
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The fragile X mental retardation protein (FMRP) is an RNA binding protein that has an essential role in neurons. From the soma to the synapse, FMRP is associated with a specific subset of messenger RNAs and controls their posttranscriptional fates, i.e., dendritic localization and local translation. Because FMRP target mRNAs encode important neuronal proteins, the deregulation of their expression in the absence of FMRP leads to a strong impairment of synaptic function. Here, we review emerging evidence indicating a critical role for FMRP in the control of mRNA stability. To date, two mRNAs have been identified as being regulated in this manner: PSD-95 mRNA, encoding a scaffolding protein, and Nxf1 mRNA, encoding a general export factor. Moreover, expression studies suggest that the turnover of other neuronal mRNAs, including those encoding for the GABA(A) receptors subunits, could be affected by the loss of FMRP. According to the specific target and/or cellular context, FMRP could influence mRNA stability in the brain.

Keywords
Animals, ELAV Proteins/genetics, ELAV Proteins/metabolism, Fragile X Mental Retardation Protein/genetics, Fragile X Mental Retardation Protein/metabolism, Heterogeneous-Nuclear Ribonucleoprotein D/genetics, Heterogeneous-Nuclear Ribonucleoprotein D/metabolism, Nerve Tissue Proteins/genetics, Neurons/cytology, Neurons/physiology, Nucleocytoplasmic Transport Proteins/genetics, RNA Stability, RNA, Messenger/genetics, RNA, Messenger/metabolism, RNA-Binding Proteins/genetics
Pubmed
Create date
06/03/2017 17:23
Last modification date
20/08/2019 15:15
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