Article: article from journal or magazin.
Mycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients.
Annales de l'Institut Pasteur. Immunology
T-cell clones capable of mounting a proliferative response to Mycobacterium leprae were obtained in three leprosy patients (two polar lepromatous and one polar tuberculoid) either from M. leprae-activated or from protein-purified derivative-activated polyclonal T lymphoblasts. All these clones expressed the CD4 surface marker. Some of them proliferated to the antigen only in the presence of interleukin-2. A majority expressed cross-reactive responses to other mycobacteria. Clones obtained from the lepromatous patients did not differ in any of these features from those obtained from the tuberculoid patient. M. leprae-reactive clones obtained from one lepromatous patient displayed strong antigen-specific cytotoxicity toward autologous antigen-coated target cells. This phenomenon was not observed for any clone of the other lepromatous patient and was seen only for one clone in the tuberculoid patient.
Antigens, Bacterial/immunology, Cell Transformation, Viral, Cells, Cultured, Clone Cells, Cytotoxicity, Immunologic, Herpesvirus 4, Human/genetics, Humans, Leprosy/immunology, Lymphocyte Activation, Mycobacterium/immunology, Mycobacterium leprae/immunology, Species Specificity, T-Lymphocytes/cytology, T-Lymphocytes/immunology
Web of science
Last modification date