Associations Between Cardiovascular Risk Factors, Inflammation, and Progression of Carotid Atherosclerosis Among Smokers.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_AB535DCED286
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Associations Between Cardiovascular Risk Factors, Inflammation, and Progression of Carotid Atherosclerosis Among Smokers.
Périodique
Nicotine & tobacco research
Auteur(s)
Zingg S., Collet T.H., Locatelli I., Nanchen D., Depairon M., Bovet P., Cornuz J., Rodondi N.
ISSN
1469-994X (Electronic)
ISSN-L
1462-2203
Statut éditorial
Publié
Date de publication
06/2016
Peer-reviewed
Oui
Volume
18
Numéro
6
Pages
1533-1538
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The high risk of cardiovascular events in smokers requires adequate control of other cardiovascular risk factors (CVRFs) to curtail atherosclerosis progression. However, it is unclear which CVRFs have the most influence on atherosclerosis progression in smokers.
In 260 smokers aged 40-70 included in a smoking cessation trial, we analyzed the association between traditional CVRFs, high-sensitivity C-reactive protein (hs-CRP), smoking cessation and 3-year progression of carotid intima-media thickness (CIMT, assessed by repeated ultrasound measurements) in a longitudinal multivariate model.
Participants (mean age 52 years, 47% women) had a mean smoking duration of 32 years with a median daily consumption of 20 cigarettes. Baseline CIMT was 1185 μm (95% confidence interval [CI]: 1082-1287) and increased by 93 μm (95% CI: 25-161) and 108 μm (95% CI: 33-183) after 1 and 3 years, respectively. Age, male sex, daily cigarette consumption, systolic blood pressure (SBP), but neither low-density lipoprotein cholesterol nor hs-CRP, were independently associated with baseline CIMT (all P ≤ .05). Baseline SBP, but neither low-density lipoprotein cholesterol nor hs-CRP, was associated with 3-year atherosclerosis progression (P = .01 at 3 years). The higher the SBP at baseline, the steeper was the CIMT increase over 3-year follow-up. We found an increase of 26 μm per each 10-mmHg raise in SBP at 1 year and an increase of 39 μm per each 10 mmHg raise in SBP at 3 years. Due to insufficient statistical power, we could not exclude an effect of smoking abstinence on CIMT progression.
Control of blood pressure may be an important factor to limit atherosclerosis progression in smokers, besides support for smoking cessation.
Among 260 smokers aged 40-70 years with a mean smoking duration of 32 years, baseline SBP was associated with atherosclerosis progression over 3 years, as measured by CIMT (P = .01 at 3 years), independently of smoking variables and other CVRFs. The higher the SBP at baseline, the steeper was the CIMT increase over 3-year follow-up. Our findings emphasize the importance of focusing not only on smoking cessation among smokers, but to simultaneously control other CVRFs, particularly blood pressure, in order to prevent future cardiovascular disease.

Mots-clé
Adult, Aged, Blood Pressure, C-Reactive Protein, Carotid Artery Diseases/complications, Carotid Artery Diseases/epidemiology, Female, Humans, Inflammation, Male, Middle Aged, Risk Factors, Smokers/statistics & numerical data, Smoking/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/02/2016 14:49
Dernière modification de la notice
20/08/2019 15:15
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