Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
HPV-11- and HPV-16-associated oral verrucous carcinoma
BACKGROUND: Verrucous carcinoma is a slowly growing, well-differentiated neoplasm with a predilection for the oral cavity. OBJECTIVE: Data on the association of human papillomavirus (HPV) with oral verrucous carcinoma are very scarce. We searched for the presence of HPV in different stages of the tumour in a patient repeatedly treated by means of surgery, cryotherapy, radiotherapy and chemotherapy over a decade. METHODS: HPV DNA was detected in archival tumour tissue by nested PCR. HPV types were identified based on restriction fragment analysis. RESULTS: HPV type 11 was found in 1 early-stage and HPV 16 in 2 late-stage biopsy specimens of the tumour. CONCLUSION: Our findings provide further evidence for a role of HPV in oral verrucous carcinoma. The case history emphasizes the importance of a joint clinicopathological approach to this tumour.
Aged Aged, 80 and over Carcinoma, Verrucous/pathology/therapy/*virology DNA, Viral/analysis Fatal Outcome Humans Male Mouth Mucosa/pathology/virology Mouth Neoplasms/pathology/therapy/*virology Papillomaviridae/*isolation & purification Papillomavirus Infections/*complications/pathology/therapy Polymerase Chain Reaction Tumor Virus Infections/*complications/pathology/therapy
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