Molecular mechanisms of chemotropism and cell fusion in unicellular fungi.

Détails

ID Serval
serval:BIB_AAB485178DB7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular mechanisms of chemotropism and cell fusion in unicellular fungi.
Périodique
Journal of cell science
Auteur(s)
Martin S.G.
ISSN
1477-9137 (Electronic)
ISSN-L
0021-9533
Statut éditorial
Publié
Date de publication
31/05/2019
Peer-reviewed
Oui
Volume
132
Numéro
11
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
In all eukaryotic phyla, cell fusion is important for many aspects of life, from sexual reproduction to tissue formation. Fungal cells fuse during mating to form the zygote, and during vegetative growth to connect mycelia. Prior to fusion, cells first detect gradients of pheromonal chemoattractants that are released by their partner and polarize growth in their direction. Upon pairing, cells digest their cell wall at the site of contact and merge their plasma membrane. In this Review, I discuss recent work on the chemotropic response of the yeast models Saccharomyces cerevisiae and Schizosaccharomyces pombe, which has led to a novel model of gradient sensing: the cell builds a motile cortical polarized patch, which acts as site of communication where pheromones are released and sensed. Initial patch dynamics serve to correct its position and align it with the gradient from the partner cell. Furthermore, I highlight the transition from cell wall expansion during growth to cell wall digestion, which is imposed by physical and signaling changes owing to hyperpolarization that is induced by cell proximity. To conclude, I discuss mechanisms of membrane fusion, whose characterization remains a major challenge for the future.
Mots-clé
Cdc42, Cell fusion, Cell polarity, Chemotropism, MAPK, Pheromone gradient, S. cerevisiae, S. pombe
Pubmed
Web of science
Création de la notice
17/06/2019 17:40
Dernière modification de la notice
21/08/2019 5:37
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