Mechanisms of uric acid crystal-mediated autoinflammation.

Details

Serval ID
serval:BIB_AA98E86CD2F3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Mechanisms of uric acid crystal-mediated autoinflammation.
Journal
Immunological Reviews
Author(s)
Martinon F.
ISSN
1600-065X (Electronic)
ISSN-L
0105-2896
Publication state
Published
Issued date
2010
Volume
233
Number
1
Pages
218-232
Language
english
Abstract
Gout is an arthritis characterized by elevated uric acid in the bloodstream. In this condition, crystals of uric acid are formed and accumulate in the synovial fluids. Crystal deposition leads to acute inflammation, which is associated with the spontaneous resolution of the disease. Recent studies have led to significant advances in the understanding of the basic biology of crystal-mediated inflammation. Uric acid has been identified as a danger signal that triggers a cytosolic sensor, the inflammasome. This signaling platform is required for the activation of interleukin-1, a cytokine that is critical to the initiation of acute inflammation in gout. Importantly, both molecular and pathological evidence support the notion that gout is a prototypical member of the growing family of autoinflammatory diseases. This review discusses the role of the inflammasome in gout and the emerging new therapeutic strategies aimed at controlling inflammation in crystal arthritis.
Keywords
Animals, Arthritis, Gouty/immunology, Arthritis, Gouty/therapy, Autoimmunity, Crystallization, Humans, Immunity, Innate, Inflammation Mediators/immunology, Signal Transduction/immunology, Uric Acid/immunology
Pubmed
Web of science
Create date
21/02/2011 15:36
Last modification date
20/08/2019 15:14
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