Article: article from journal or magazin.
The transcription factor c-Maf controls touch receptor development and function.
Science (new York, N.y.)
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The sense of touch relies on detection of mechanical stimuli by specialized mechanosensory neurons. The scarcity of molecular data has made it difficult to analyze development of mechanoreceptors and to define the basis of their diversity and function. We show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function in mice and humans. The development and function of several rapidly adapting mechanoreceptor types are disrupted in c-Maf mutant mice. In particular, Pacinian corpuscles, a type of mechanoreceptor specialized to detect high-frequency vibrations, are severely atrophied. In line with this, sensitivity to high-frequency vibration is reduced in humans carrying a dominant mutation in the c-MAF gene. Thus, our work identifies a key transcription factor specifying development and function of mechanoreceptors and their end organs.
Animals, Ganglia, Spinal/cytology, Ganglia, Spinal/embryology, Gene Expression Regulation, Developmental, Humans, Maf Transcription Factors, Large/genetics, Maf Transcription Factors, Large/metabolism, Mechanoreceptors/cytology, Mechanoreceptors/physiology, Mice, Mutation, Pacinian Corpuscles/cytology, Pacinian Corpuscles/physiology, Proto-Oncogene Proteins c-maf/genetics, Proto-Oncogene Proteins c-maf/metabolism, Proto-Oncogene Proteins c-ret/genetics, Proto-Oncogene Proteins c-ret/metabolism, Skin/innervation, Touch, Vibration
Web of science
Last modification date