The transcription factor c-Maf controls touch receptor development and function.

Détails

ID Serval
serval:BIB_AA644288E95F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The transcription factor c-Maf controls touch receptor development and function.
Périodique
Science (new York, N.y.)
Auteur(s)
Wende H., Lechner S.G., Cheret C., Bourane S., Kolanczyk M.E., Pattyn A., Reuter K., Munier F.L., Carroll P., Lewin G.R., Birchmeier C.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
335
Numéro
6074
Pages
1373-1376
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The sense of touch relies on detection of mechanical stimuli by specialized mechanosensory neurons. The scarcity of molecular data has made it difficult to analyze development of mechanoreceptors and to define the basis of their diversity and function. We show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function in mice and humans. The development and function of several rapidly adapting mechanoreceptor types are disrupted in c-Maf mutant mice. In particular, Pacinian corpuscles, a type of mechanoreceptor specialized to detect high-frequency vibrations, are severely atrophied. In line with this, sensitivity to high-frequency vibration is reduced in humans carrying a dominant mutation in the c-MAF gene. Thus, our work identifies a key transcription factor specifying development and function of mechanoreceptors and their end organs.
Mots-clé
Animals, Ganglia, Spinal/cytology, Ganglia, Spinal/embryology, Gene Expression Regulation, Developmental, Humans, Maf Transcription Factors, Large/genetics, Maf Transcription Factors, Large/metabolism, Mechanoreceptors/cytology, Mechanoreceptors/physiology, Mice, Mutation, Pacinian Corpuscles/cytology, Pacinian Corpuscles/physiology, Proto-Oncogene Proteins c-maf/genetics, Proto-Oncogene Proteins c-maf/metabolism, Proto-Oncogene Proteins c-ret/genetics, Proto-Oncogene Proteins c-ret/metabolism, Skin/innervation, Touch, Vibration
Pubmed
Web of science
Création de la notice
21/02/2013 9:39
Dernière modification de la notice
20/08/2019 15:14
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