Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction

Details

Serval ID
serval:BIB_A9DE65BAF799
Type
Article: article from journal or magazin.
Collection
Publications
Title
Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction
Journal
Journal of Clinical Investigation
Author(s)
Fumeron F., Betoulle D., Luc G., Behague I., Ricard S., Poirier O., Jemaa R., Evans A., Arveiler D., Marques-Vidal P.
ISSN
0021-9738 (Print)
ISSN-L
0021-9738
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
96
Number
3
Pages
1664-1671
Language
english
Notes
Publication types: Research Article ; research-article
Identifiant PubMed Central: PMC185794
Abstract
A polymorphism of the CETP gene (CETP/TaqIB) with two alleles B1 (60%) and B2 (40%) has been investigated in relation to lipid variables and the risk of myocardial infarction in a large case-control study (ECTIM) of men aged 25-64. No association was observed between the polymorphism and LDL or VLDL related lipid variables. Conversely, B2 carriers had reduced levels of plasma CETP (P < 0.0001) and increased levels of HDL cholesterol (P < 0.0001) and of other HDL related lipid variables. The effects of the polymorphism on plasma CETP and HDL cholesterol were independent, suggesting the presence of at least two functional variants linked to B2. A search for these variants on the coding sequence of the CETP gene failed to identify them. The effect of B2 on plasma HDL cholesterol was absent in subjects drinking < 25 grams/d of alcohol but increased commensurably, with higher values of alcohol consumption (interaction: P < 0.0001). A similar interaction was not observed for plasma CETP. The odds-ratio for myocardial infarction of B2 homozygotes decreased from 1.0 in nondrinkers to 0.34 in those drinking 75 grams/d or more. These results provide the first demonstration of a gene-environment interaction affecting HDL cholesterol levels and coronary heart disease risk.
Keywords
Alcohol Drinking/metabolism, Carrier Proteins/biosynthesis, Carrier Proteins/genetics, Cholesterol Esters/metabolism, Lipoproteins, HDL/blood, Lipoproteins, LDL/blood, Lipoproteins, VLDL/blood, Myocardial Infarction/epidemiology, Myocardial Infarction/genetics
Pubmed
Web of science
Open Access
Yes
Create date
01/12/2016 15:02
Last modification date
20/08/2019 15:14
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