Article: article from journal or magazin.
Cutaneous human papillomavirus in head and neck squamous cell carcinomas.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
To evaluate the prevalence and meaning of cutaneous human papillomavirus (HPV) types in HNSCC 51 patients were analyzed for the prevalence of cutaneous as well as mucosal HPV. HPV DNA was demonstrated in 18 (35%) of 51 tumors. The majority of these HPV types belong to so-called cutaneous HPV types, whereas only HPV 6 and HPV 16 were from the mucosal HPV types. A possible role for cutaneous HPV types as co-factors in the oncogenesis of HNSCC remains to be elucidated and may be relevant for future strategies of cancer prevention.
Aged, Alcohol Drinking/epidemiology, Alphapapillomavirus/classification, Alphapapillomavirus/isolation & purification, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Carboplatin/administration & dosage, Carcinoma, Squamous Cell/drug therapy, Carcinoma, Squamous Cell/radiotherapy, Cell Transformation, Viral, Combined Modality Therapy, DNA Probes, HPV, DNA, Viral/analysis, Disease-Free Survival, Dose Fractionation, Fluorouracil/administration & dosage, Head and Neck Neoplasms/drug therapy, Head and Neck Neoplasms/radiotherapy, Humans, Male, Middle Aged, Mucous Membrane/virology, Organ Specificity, Papillomavirus Infections/epidemiology, Papillomavirus Infections/virology, Prevalence, Risk Factors, Skin/virology, Smoking/epidemiology
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