Long Noncoding RNAs in Cancer and Therapeutic Potential.

Détails

ID Serval
serval:BIB_A94A89BA2542
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Long Noncoding RNAs in Cancer and Therapeutic Potential.
Périodique
Advances in Experimental Medicine and Biology
Auteur(s)
Renganathan A., Felley-Bosco E.
ISBN
9789811052026
9789811052033
ISSN
0065-2598 (Print)
ISSN-L
0065-2598
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
1008
Pages
199-222
Langue
anglais
Résumé
Long noncoding RNAs (lncRNAs) are the major elements of the mammalian transcriptome that is emerging as a central player controlling diverse cellular mechanisms. Most of the well-studied lncRNAs so far are found to be crucial in regulating cellular processes such as cell cycle, growth, and apoptosis that ensure homeostasis. Owing to their location and distribution in the genome, lncRNAs influence the transcription of a wide range of proteins directly or indirectly by transcriptional and posttranscriptional alterations, which opens up the "LncRNA-cancer paradigm" in a context-dependent manner, i.e., either oncogenic or tumor suppressive. Thus, this chapter is a consolidation of lncRNA association in exhibiting or suppressing the typical cancer hallmarks such as continuous proliferation, surpassing apoptosis, genomic instability, drug resistance, invasion, and metastasis studied till date. In addition, special focus has been given on the efficient application of lncRNAs as potential targets for therapeutics that holds a great promise for future cancer therapy.

Mots-clé
Animals, Apoptosis, Cell Cycle, Drug Resistance, Neoplasm/genetics, Genomic Instability, Humans, Neoplasm Invasiveness, Neoplasm Proteins/biosynthesis, Neoplasm Proteins/genetics, Neoplasms/genetics, Neoplasms/metabolism, Neoplasms/pathology, RNA, Long Noncoding/genetics, RNA, Long Noncoding/metabolism, RNA, Neoplasm/genetics, RNA, Neoplasm/metabolism, Transcription, Genetic, Antisense oligonucleotides, Cancer, Chemoresistance, Epigenetic regulation, Gene regulation, Natural antisense transcripts, Therapeutic target, ceRNA
Pubmed
Création de la notice
01/01/2018 16:09
Dernière modification de la notice
20/08/2019 15:13
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