The Metabolic Benefits of Menopausal Hormone Therapy Are Not Mediated by Improved Nutritional Habits. The OsteoLaus Cohort.

Détails

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Etat: Public
Version: de l'auteur
Licence: CC BY 4.0
ID Serval
serval:BIB_A93571549972
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Metabolic Benefits of Menopausal Hormone Therapy Are Not Mediated by Improved Nutritional Habits. The OsteoLaus Cohort.
Périodique
Nutrients
Auteur(s)
Papadakis G.E., Hans D., Gonzalez Rodriguez E., Vollenweider P., Waeber G., Marques-Vidal P., Lamy O.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Statut éditorial
Publié
Date de publication
16/08/2019
Peer-reviewed
Oui
Volume
11
Numéro
8
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Menopause alters body composition by increasing fat mass. Menopausal hormone therapy (MHT) is associated with decreased total and visceral adiposity. It is unclear whether MHT favorably affects energy intake. We aimed to assess in the OsteoLaus cohort whether total energy intake (TEI) and/or diet quality (macro- and micronutrients, dietary patterns, dietary scores, dietary recommendations)-evaluated by a validated food frequency questionnaire-differ in 839 postmenopausal women classified as current, past or never MHT users. There was no difference between groups regarding TEI or consumption of macronutrients. After multivariable adjustment, MHT users were less likely to adhere to the unhealthy pattern 'fat and sugar: Current vs. never users [OR (95% CI): 0.48 (0.28-0.82)]; past vs. never users [OR (95% CI): 0.47 (0.27-0.78)]. Past users exhibited a better performance in the revised score for Mediterranean diet than never users (5.00 ± 0.12 vs. 4.63 ± 0.08, p < 0.04). Differences regarding compliance with dietary recommendations were no longer significant after adjustment for covariates. Overall, these results argue against a major role of TEI and diet quality as possible mediators of the MHT metabolic benefits. Future research on this relationship should focus on other potential targets of MHT, such as resting energy expenditure and physical activity.
Mots-clé
Aged, Cohort Studies, Diet, Feeding Behavior, Female, Hormone Replacement Therapy, Humans, Menopause, Middle Aged, Postmenopause, Risk Factors, dietary patterns, dietary recommendations, energy intake, estrogen deficiency, estrogens, macronutrients, menopausal hormone therapy, menopause, visceral fat
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/08/2019 14:02
Dernière modification de la notice
18/02/2020 6:20
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