Susceptibility to hard metal lung disease is strongly associated with the presence of glutamate 69 in HLA-DP beta chain
Details
Serval ID
serval:BIB_A89834C417BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Susceptibility to hard metal lung disease is strongly associated with the presence of glutamate 69 in HLA-DP beta chain
Journal
European Journal of Immunology
ISSN
0014-2980 (Print)
Publication state
Published
Issued date
10/1997
Volume
27
Number
10
Pages
2741-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Abstract
Clinical, epidemiological and experimental data indicate that inhaled metal dust containing cobalt may produce an interstitial lung disease termed "hard metal disease" (HMD). Some aspects of this pathology such as the lack of correlation with dose exposure, the low frequency of the disease and the presence of T cells in the inflammation site, all suggest the existence of a genetic susceptibility, possibly to an immunological response to cobalt or to self proteins modified by cobalt. Here we report that HMD is strongly associated with residue Glu-69 of the HLA-DP beta chain. All patients, except for one with a rare genotype, possessed this marker as compared to 17 out of 35 exposed unaffected individuals (p = 0.0014). These data allow us to genetically distinguish a subgroup of cobalt-exposed individuals at risk for HMD, independently from the more common allergic reaction.
Keywords
Adult
Air Pollutants, Occupational/*adverse effects
Amino Acid Sequence
Belgium/epidemiology
Cobalt/*adverse effects
Codon/genetics
Disease Susceptibility
Female
Genotype
Glutamic Acid
HLA-DP Antigens/chemistry/*genetics
Humans
Italy/epidemiology
Male
*Metallurgy
Molecular Sequence Data
Occupational Diseases/epidemiology/etiology/*genetics/immunology
Pneumoconiosis/epidemiology/etiology/genetics/immunology
Pulmonary Fibrosis/epidemiology/etiology/*genetics/immunology
Sequence Alignment
Sequence Homology, Amino Acid
Pubmed
Web of science
Create date
25/01/2008 15:16
Last modification date
20/08/2019 15:13