Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis.

Détails

Ressource 1Télécharger: s12864-017-3531-y.pdf (1112.96 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_A87ECF2238E9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis.
Périodique
BMC genomics
Auteur(s)
Gschwind A.R., Singh A., Certa U., Reymond A., Heckel T.
ISSN
1471-2164 (Electronic)
ISSN-L
1471-2164
Statut éditorial
Publié
Date de publication
10/02/2017
Peer-reviewed
Oui
Volume
18
Numéro
1
Pages
144
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Copy number variations (CNVs) are a significant source of genetic diversity and commonly found in mammalian genomes. We have generated a genome-wide CNV map for Cynomolgus monkeys (Macaca fascicularis). This crab-eating macaque is the closest animal model to humans that is used in biomedical research.
We show that Cynomolgus monkey CNVs are in general much smaller in size than gene loci and are specific to the population of origin. Genome-wide expression data from five vitally important organs demonstrates that CNVs in close proximity to transcription start sites associate strongly with expression changes. Among these eQTL genes we find an overrepresentation of genes involved in metabolism, receptor activity, and transcription.
These results provide evidence that CNVs shape tissue transcriptomes in monkey populations, potentially offering an adaptive advantage. We suggest that this genetic diversity should be taken into account when using Cynomolgus macaques as models.

Mots-clé
Animals, DNA Copy Number Variations, Gene Expression Profiling, Genotype, Macaca fascicularis/genetics, Quantitative Trait Loci/genetics, CNV, Cynomolgus monkey, Gene expression, Olfactory receptors, eQTL
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/02/2017 20:10
Dernière modification de la notice
20/08/2019 16:12
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