Grueneberg ganglion cells mediate alarm pheromone detection in mice.

Détails

ID Serval
serval:BIB_A82FB170C60C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Grueneberg ganglion cells mediate alarm pheromone detection in mice.
Périodique
Science
Auteur(s)
Brechbühl J., Klaey M., Broillet M.C.
ISSN
1095-9203[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
321
Numéro
5892
Pages
1092-1095
Langue
anglais
Résumé
Alarm pheromones (APs) are widely used throughout the plant and animal kingdoms. Species such as fish, insects, and mammals signal danger to conspecifics by releasing volatile alarm molecules. Thus far, neither the chemicals, their bodily source, nor the sensory system involved in their detection have been isolated or identified in mammals. We found that APs are recognized by the Grueneberg ganglion (GG), a recently discovered olfactory subsystem. We showed with electron microscopy that GG neurons bear primary cilia, with cell bodies ensheathed by glial cells. APs evoked calcium responses in GG neurons in vitro and induced freezing behavior in vivo, which completely disappeared when the GG degenerated after axotomy. We conclude that mice detect APs through the activation of olfactory GG neurons.
Mots-clé
Animal Communication, Animals, Animals, Newborn, Axotomy, Behavior, Animal, Calcium/metabolism, Cilia/ultrastructure, Female, Ganglia, Sensory/physiology, Ganglia, Sensory/ultrastructure, Mice, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Nasal Mucosa/cytology, Nasal Mucosa/innervation, Neuroglia/ultrastructure, Neurons, Afferent/physiology, Neurons, Afferent/ultrastructure, Permeability, Pheromones/analysis, Stress, Physiological
Pubmed
Web of science
Création de la notice
17/09/2008 15:29
Dernière modification de la notice
20/08/2019 16:12
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