Precision oncology by point-of-care therapeutic drug monitoring and dosage adjustment of conventional cytotoxic chemotherapies: A perspective.

Details

Ressource 1Download: pharmaceutics-15-01283.pdf (366.73 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_A82A8DDE8796
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Precision oncology by point-of-care therapeutic drug monitoring and dosage adjustment of conventional cytotoxic chemotherapies: A perspective.
Journal
Pharmaceutics
Author(s)
Briki M., André P., Thoma Y., Widmer N., Wagner A.D., Decosterd L.A., Buclin T., Guidi M., Carrara S.
ISSN
1999-4923 (Print)
ISSN-L
1999-4923
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
15
Number
4
Pages
1283
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Therapeutic drug monitoring (TDM) of conventional cytotoxic chemotherapies is strongly supported yet poorly implemented in daily practice in hospitals. Analytical methods for the quantification of cytotoxic drugs are instead widely presented in the scientific literature, while the use of these therapeutics is expected to keep going for longer. There are two main issues hindering the implementation of TDM: turnaround time, which is incompatible with the dosage profiles of these drugs, and exposure surrogate marker, namely total area under the curve (AUC). Therefore, this perspective article aims to define the adjustment needed from current to efficient TDM practice for cytotoxics, namely point-of-care (POC) TDM. For real-time dose adjustment, which is required for chemotherapies, such POC TDM is only achievable with analytical methods that match the sensitivity and selectivity of current methods, such as chromatography, as well as model-informed precision dosing platforms to assist the oncologist with dose fine-tuning based on quantification results and targeted intervals.
Keywords
therapeutic drug monitoring, point-of-care, oncology, cytotoxics
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 200021_207900
Create date
21/04/2023 13:39
Last modification date
07/06/2023 5:57
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