Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates
Details
Serval ID
serval:BIB_A804A101CFD3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates
Journal
Natural Medicines
ISSN
1078-8956
Publication state
Published
Issued date
07/2006
Peer-reviewed
Oui
Volume
12
Number
7
Pages
790-2
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody.
Keywords
Animals
Antibodies/*therapeutic use
Cervix Uteri/physiopathology
Disease Models, Animal
Female
Macaca
Motor Activity/*drug effects
Myelin Proteins/*immunology
Uterine Cervical Diseases/*immunology
Pubmed
Web of science
Create date
06/02/2008 10:03
Last modification date
20/08/2019 15:12
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