Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid.
Details
Serval ID
serval:BIB_A795723CCF5A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnostic relevance of direct immunofluorescence in ocular mucous membrane pemphigoid.
Journal
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology
ISSN
1610-0387 (Electronic)
ISSN-L
1610-0379
Publication state
Published
Issued date
12/2015
Peer-reviewed
Oui
Volume
13
Number
12
Pages
1268-1274
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The objective was to determine the diagnostic value of direct immunofluorescence (DIF) in ocular mucous membrane pemphigoid (ocular MMP), taking into account immunofluorescence patterns and biopsy sites.
DIF results and medical records of 54 patients with a suspected diagnosis of ocular MMP were reviewed.
There was an overall prevalence of ocular MMP in 70.4 % of cases. Linear deposition of IgA, IgG, or C3 showed a high positive predictive value (84-100 %). Sensitivity and negative predictive value of IgG, IgM, IgG, and C3 in DIF were higher in cutaneous samples than in conjunctival biopsies, thus yielding a higher diagnostic accuracy. The sensitivity of DIF in ocular MMP seems to be lower than in bullous pemphigoid.
The diagnostic value of DIF in the workup of ocular MMP was confirmed. However, biopsies taken from non-conjunctival, cutaneous tissue appear to yield more accurate results.
DIF results and medical records of 54 patients with a suspected diagnosis of ocular MMP were reviewed.
There was an overall prevalence of ocular MMP in 70.4 % of cases. Linear deposition of IgA, IgG, or C3 showed a high positive predictive value (84-100 %). Sensitivity and negative predictive value of IgG, IgM, IgG, and C3 in DIF were higher in cutaneous samples than in conjunctival biopsies, thus yielding a higher diagnostic accuracy. The sensitivity of DIF in ocular MMP seems to be lower than in bullous pemphigoid.
The diagnostic value of DIF in the workup of ocular MMP was confirmed. However, biopsies taken from non-conjunctival, cutaneous tissue appear to yield more accurate results.
Keywords
Adult, Aged, Aged, 80 and over, Biomarkers/analysis, Cytokines/immunology, Female, Fluorescent Antibody Technique, Direct/methods, Humans, Male, Middle Aged, Pemphigoid, Benign Mucous Membrane/diagnosis, Pemphigoid, Benign Mucous Membrane/immunology, Reproducibility of Results, Sensitivity and Specificity
Pubmed
Web of science
Publisher's website
Create date
27/08/2020 14:59
Last modification date
18/05/2022 6:36
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