Subnanogram GC/NPD method for the determination of sparteine in biological fluids.

Details

Serval ID
serval:BIB_A6DDF215688E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Subnanogram GC/NPD method for the determination of sparteine in biological fluids.
Journal
Methods and Findings In Experimental and Clinical Pharmacology
Author(s)
Kintz P., Tracqui A., Mangin P., Lugnier A., Chaumont A.
ISSN
0379-0355[print], 0379-0355[linking]
Publication state
Published
Issued date
1989
Volume
11
Number
2
Pages
115-118
Language
english
Abstract
A gas chromatographic method is presented for identification and quantification of sparteine in biological fluids using cyclizine as an internal standard. No derivation is necessary and after a single alkaline extraction, GC analysis of sparteine is achieved in less than 8 min. A subnanogram limit of detection is allowed by the use of a nitrogen phosphorous detector (NPD). This method is simple, reproducible, selective, and applicable in both clinical and pharmacokinetic studies.
Keywords
Chromatography, Gas, Humans, Indicators and Reagents, Sparteine/analysis, Sparteine/blood
Pubmed
Create date
15/10/2010 13:00
Last modification date
20/08/2019 15:11
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