Article: article from journal or magazin.
Subnanogram GC/NPD method for the determination of sparteine in biological fluids.
Methods and Findings In Experimental and Clinical Pharmacology
A gas chromatographic method is presented for identification and quantification of sparteine in biological fluids using cyclizine as an internal standard. No derivation is necessary and after a single alkaline extraction, GC analysis of sparteine is achieved in less than 8 min. A subnanogram limit of detection is allowed by the use of a nitrogen phosphorous detector (NPD). This method is simple, reproducible, selective, and applicable in both clinical and pharmacokinetic studies.
Chromatography, Gas, Humans, Indicators and Reagents, Sparteine/analysis, Sparteine/blood
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