Higher retinal vessel oxygen saturation: investigating its relationship with macular oedema in retinitis pigmentosa patients.

Details

Serval ID
serval:BIB_A6D786D52826
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Higher retinal vessel oxygen saturation: investigating its relationship with macular oedema in retinitis pigmentosa patients.
Journal
Eye
Author(s)
Bojinova R.I., Schorderet D.F., Valmaggia C., Türksever C., Schoetzau A., Todorova M.G.
ISSN
1476-5454 (Electronic)
ISSN-L
0950-222X
Publication state
Published
Issued date
07/2018
Peer-reviewed
Oui
Volume
32
Number
7
Pages
1209-1219
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Primary objective-to investigate the effect of retinal vessel oxygen saturation (SO <sub>2</sub> ) on macular oedema (ME) in retinitis pigmentosa (RP) patients. Secondary objective-to link the presence of ME to metabolic (oxygen saturation of retinal vessels, SO <sub>2</sub> ), functional (multifocal electroretinography, mfERG) and structural (Spectral Domain Optical Coherent Tomography, SD-OCT) alterations in RP.
Prospective, cross-sectional, non-interventional study.
Patients with typical RP (N = 37) and controls (N = 19), who underwent retinal vessel Oximetry (RO), SD-OCT and mfERG, were included.
A computer-based program of the retinal vessel analyser unit (IMEDOS Systems UG, Jena, Germany) was used to measure SO <sub>2</sub> . We evaluated the mean SO <sub>2</sub> , in all major retinal arterioles (oxygen saturation in retinal arterioles, A-SO <sub>2</sub> , %) and venules (oxygen saturation in retinal venules, V-SO <sub>2</sub> , %). MfERG responses were averaged in zones (zone 1 (0-3°), zone 2 (3-8°) and zone 3 (8-15°)) and compared to corresponding areas of the OCT. The effect of ME on SO <sub>2</sub> was evaluated dividing the RP in two subgroups: with clinical appearance of ME (ME-RP) and without it (no-ME-RP).
Parallel recording and juxtaposition of metabolic (SO <sub>2</sub> ) to structural (OCT) and functional-(mfERG) measures. Mean ( ± SD) A-SO <sub>2</sub> and V-SO <sub>2</sub> were higher in no-ME-RP (96.77% (±6.31) and 59.93% (±7.76)) and even higher in the ME-RP (99.82% (±6.21) and 65.63% (±7.63)), compared to controls (93.15% (±3.76) and 53.77% (±3.70), p ≤ 0.006).
The subgroup ME-RP differed significantly from the subgroup no-ME-RP by increased A-SO <sub>2</sub> and V-SO <sub>2</sub> , p ≤ 0.026. The presence of ME confirmed a different relationship between the altered SO <sub>2</sub> and the vessel diameters, against the functional and structural parameters.
Based on our results, the presence of macular oedema indicates a tendency toward greater alteration of the metabolic function in RP patients.
Pubmed
Web of science
Create date
10/03/2018 9:23
Last modification date
20/08/2019 15:11
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