Management of locally advanced anal canal carcinoma with intensity-modulated radiotherapy and concurrent chemotherapy.

Détails

ID Serval
serval:BIB_A69931C0EE76
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Management of locally advanced anal canal carcinoma with intensity-modulated radiotherapy and concurrent chemotherapy.
Périodique
Medical oncology
Auteur(s)
Klausner G., Blais E., Jumeau R., Biau J., de Meric de Bellefon M., Ozsahin M., Zilli T., Miralbell R., Thariat J., Troussier I.
ISSN
1559-131X (Electronic)
ISSN-L
1357-0560
Statut éditorial
Publié
Date de publication
20/08/2018
Peer-reviewed
Oui
Volume
35
Numéro
10
Pages
134
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
The best curative option for locally advanced (stages II-III) squamous-cell carcinomas of the anal canal (SCCAC) is concurrent chemo-radiotherapy delivering 36-45 Gy to the prophylactic planning target volume with an additional boost of 14-20 Gy to the gross tumor volume with or without a gap-period between these two sequences. Although 3-dimensional conformal radiotherapy led to suboptimal tumor coverage because of field junctions, this modality remains a standard of care. Recently, intensity-modulated radiotherapy (IMRT) techniques improved tumor coverage while decreasing doses delivered to organs at risk. Sparing healthy tissues results in fewer severe acute toxicities. Consequently, IMRT could potentially avoid a gap-period that may increase the risk of local failure. Furthermore, these modalities reduce severe late toxicities of the gastrointestinal tract as well as better functional conservation of anorectal sphincter. This report aims to critically review contemporary trends in the management of locally advanced SCCAC using IMRT and concurrent chemotherapy.
Mots-clé
Antineoplastic Agents/administration & dosage, Anus Neoplasms/diagnostic imaging, Anus Neoplasms/therapy, Carcinoma, Squamous Cell/diagnostic imaging, Carcinoma, Squamous Cell/therapy, Combined Modality Therapy/methods, Disease Management, Humans, Neoplasm Staging/methods, Radiotherapy, Intensity-Modulated/methods, Anal canal, Cancer, Chemo-radiotherapy, Helical tomotherapy, Intensity-modulated radiation therapy, Squamous-cell carcinoma, Volumetric modulated arc therapy
Pubmed
Web of science
Création de la notice
16/09/2018 17:08
Dernière modification de la notice
20/08/2019 15:11
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