Current recommendations for the management of neurocognitive complaints in people living with HIV (PLWH) include a series of evaluations that may start with the exclusion of depression followed by a stepwise approach comprised by neurological, neuropsychological and psychiatric assessment, alongside the performance of an MRI and a lumbar puncture. This extensive evaluation is time demanding, and face PLHW with multiple medical consultations and waiting lists. As a response to these challenges, we have developed a one-day Neuro-HIV platform where PLWH undergo a state of the art multidisciplinary assessment in order to provide the necessary diagnoses and interventions to improve their quality of life.