Electrical colonic stimulation reduces mean transit time in a porcine model.

Détails

ID Serval
serval:BIB_A51AC6060FA2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Electrical colonic stimulation reduces mean transit time in a porcine model.
Périodique
Neurogastroenterology and motility
Auteur(s)
Vaucher J., Cerantola Y., Gie O., Letovanec I., Virag N., Demartines N., Gardaz J.P., Givel J.C.
ISSN
1365-2982[electronic]
Statut éditorial
Publié
Date de publication
2010
Volume
22
Pages
88-92, e31
Langue
anglais
Résumé
Abstract Electrical stimulation is a new way to treat digestive disorders such as constipation. Colonic propulsive activity can be triggered by battery operated devices. This study aimed to demonstrate the effect of direct electrical colonic stimulation on mean transit time in a chronic porcine model. The impact of stimulation and implanted material on the colonic wall was also assessed. Three pairs of electrodes were implanted into the caecal wall of 12 anaesthetized pigs. Reference colonic transit time was determined by radiopaque markers for each pig before implantation. It was repeated 4 weeks after implantation with sham stimulation and 5 weeks after implantation with electrical stimulation. Aboral sequential trains of 1-ms pulse width (10 V; 120 Hz) were applied twice daily for 6 days, using an external battery operated stimulator. For each course of markers, a mean value was computed from transit times obtained from individual pig. Microscopic examination of the caecum was routinely performed after animal sacrifice. A reduction of mean transit time was observed after electrical stimulation (19 +/- 13 h; mean +/- SD) when compared to reference (34 +/- 7 h; P = 0.045) and mean transit time after sham stimulation (36 +/- 9 h; P = 0.035). Histological examination revealed minimal chronic inflammation around the electrodes. Colonic transit time measured in a chronic porcine model is reduced by direct sequential electrical stimulation. Minimal tissue lesion is elicited by stimulation or implanted material. Electrical colonic stimulation could be a promising approach to treat specific disorders of the large bowel.
Pubmed
Web of science
Création de la notice
01/10/2009 10:24
Dernière modification de la notice
20/08/2019 16:10
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