Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway.

Détails

ID Serval
serval:BIB_A5147655526B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway.
Périodique
American Journal of Pathology
Auteur(s)
Obregon C., Rothen-Rutishauser B., Gerber P., Gehr P., Nicod L.P.
ISSN
1525-2191[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
175
Numéro
2
Pages
696-705
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Dendritic cells (DCs) can release hundreds of membrane vesicles, called exovesicles, which are able to activate resting DCs and distribute antigen. Here, we examined the role of mature DC-derived exovesicles in innate and adaptive immunity, in particular their capacity to activate epithelial cells. Our analysis of exovesicle contents showed that exovesicles contain major histocompatibility complex-II, CD40, and CD83 molecules in addition to tumor necrosis factor (TNF) receptors, TNFRI and TNFRII, and are important carriers of TNF-alpha. These exovesicles are rapidly internalized by epithelial cells, inducing the release of cytokines and chemokines, but do not transfer an alloantigen-presenting capacity to epithelial cells. Part of this activation appears to involve the TNF-alpha-mediated pathway, highlighting the key role of DC-derived exovesicles, not only in adaptive immunity, but also in innate immunity by triggering innate immune responses and activating neighboring epithelial cells to release cytokines and chemokines, thereby amplifying the magnitude of the innate immune response.
Pubmed
Web of science
Création de la notice
21/10/2009 15:22
Dernière modification de la notice
03/03/2018 20:14
Données d'usage