Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia.

Détails

ID Serval
serval:BIB_A4FEB58F8AAA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia.
Périodique
Journal of forensic and legal medicine
Auteur(s)
Descloux E., Augsburger M., Teresiński G., Hejna P., Grouzmann E., Scarpelli M.P., Hervet T., Palmiere C.
ISSN
1878-7487 (Electronic)
ISSN-L
1752-928X
Statut éditorial
Publié
Date de publication
08/2017
Peer-reviewed
Oui
Volume
50
Pages
39-43
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells. In the study herein described, endocan concentrations were determined in postmortem serum, urine and vitreous humor samples collected during autopsy in a series of cases that underwent medicolegal investigations. A total of 76 autopsy cases were selected and three study groups (hypothermia group, sepsis group and non-hypothermia/non-sepsis group) prospectively formed during the study period. The obtained results seem to indicate that exposure to cold and subsequent death is not distinguished by significant endothelial dysfunction causing enhanced endocan secretion.

Mots-clé
Autopsy, Endocan, Endothelium, Hypothermia, Postmortem biochemistry, Postmortem serum, Urine, Vitreous humor
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/07/2017 9:49
Dernière modification de la notice
08/05/2019 23:11
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