Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment.

Détails

ID Serval
serval:BIB_A4EEAB69A9FB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment.
Périodique
Molecular pharmaceutics
Auteur(s)
Riedel T., Demaria O., Zava O., Joncic A., Gilliet M., Dyson P.J.
ISSN
1543-8392 (Electronic)
ISSN-L
1543-8384
Statut éditorial
Publié
Date de publication
02/01/2018
Peer-reviewed
Oui
Volume
15
Numéro
1
Pages
116-126
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
By screening a drug library comprising FDA approved compounds, we discovered a potent interaction between the antifungal agent haloprogin and the experimental organometallic drug RAPTA-T, to synergistically induce cancer cell killing. The combination of these two small molecules, even at low doses, elicited an improved therapeutic response on tumor growth over either agent alone or the current treatment used in the clinic in the highly aggressive syngeneic B16F10 melanoma tumor model, where classical cytotoxic chemotherapeutic agents show little efficacy. The combination with the repurposed chemodrug haloprogin provides the basis for a new powerful treatment option for cutaneous melanoma. Importantly, because synergistic induction of tumor cell death is achieved with low individual drug doses, and cellular targets for RAPTA-T are different from those of classical chemotherapeutic drugs, a therapeutic strategy based on this approach could avoid toxicities and potentially resistance mechanisms, and could even inhibit metastatic progression.
Mots-clé
RAPTA-T, antifungal agent, drug discovery, haloprogin, high-throughput screening, melanoma, organometallic drug
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/11/2018 12:25
Dernière modification de la notice
08/05/2019 23:11
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