Purpura of the face and neck: an atypical clinical presentation revealing a hepatosplenic T cell lymphoma

Détails

Ressource 1Télécharger: BIB_A4DCA0AC9D4C.P001.pdf (838.99 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_A4DCA0AC9D4C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Purpura of the face and neck: an atypical clinical presentation revealing a hepatosplenic T cell lymphoma
Périodique
Case Reports in Dermatology
Auteur(s)
Kuonen F., Bucher M., de Leval L., Vernez M., Gilliet M., Conrad C., Feldmeyer L.
ISSN
1662-6567 (Electronic)
ISSN-L
1662-6567
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
6
Numéro
1
Pages
37-42
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish, pdf : We describe a case
Résumé
BACKGROUND: Hepatosplenic T cell lymphoma (HSTL) is a rare but very aggressive peripheral T cell lymphoma whose initial silent clinical presentation unfortunately delays the diagnosis and worsens the prognosis of patient survival. Efforts should be aimed at early recognition and treatment. METHODS: We describe a case of a 62-year-old woman who presented at our clinic with a non-palpable purpuric eruption of the face. Investigations revealed thrombocytopenia with hepatosplenomegaly, which showed rapid progression together with accentuation of the purpura. Two months later, a bone marrow biopsy revealed the diagnosis of a HSTL. RESULTS: The patient received six cycles of CHOP chemotherapy (vincristine, cyclophosphamide, doxorubicin, methylprednisolone) followed by a well-tolerated autologous bone marrow graft. Normalization of the platelet count resulted in regression of the purpuric rash. CONCLUSION: To our knowledge, this is the first report of a facial thrombocytopenic purpura as the inaugural symptom of HSTL. It emphasizes the privileged position of the dermatologist for early recognition of potentially lethal HSTL.
Pubmed
Open Access
Oui
Création de la notice
08/04/2014 15:35
Dernière modification de la notice
08/05/2019 23:10
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