Herpes simplex encephalitis and management of acyclovir in encephalitis patients in France.
Details
Serval ID
serval:BIB_A4D89D0EFD7F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Herpes simplex encephalitis and management of acyclovir in encephalitis patients in France.
Journal
Epidemiology and infection
Working group(s)
Steering Committee and Investigators Group
Contributor(s)
Bébéar C., Brouard C., De Broucker T., Cua E., Dabernat H., Floret D., Guéry B., Lecuit M., Lévy-Bruhl D., Lina B., Lortholary O., Mailles A., Manuguerra J.C., Morand P., Michelet C., Peigue-Lafeuille H., Pozzetto B., Stahl J.P., Vaillant V., Yazdanpanah Y., Zeller H., Abboud P., Alloui C., Archimbaud C., Barroso B., Bernard L., Beuret P., Billaud G., Blanc T., Bonnard-Gougeon M., Boutolleau D., Bretonnière C., Bressollette-Bodin C., Bruneel F., Buisson M., Caramella A., Castan B., Cattaneo I., Cazanave C., Chabrier S., Chadenat M.L., Chambon M., Chavanet P., Chouchane M., Clavelou P., Courant P., Cua E., de Brabant F., De La Blanchardière A., De La Gastine G., De Montclos H., Denes E., Desprez P., Dewilde A., Dinh A., Durand F., Emeriaud G., Epaulard O., Favaretto G., Ferrier A., Foulongne V., Fourrier F., Gaday V., Gaillat J., Gallet S., Gau M.A., Gazuy N., Georges H., Gouarin S., Goubin P., Goudeau A., Gozlan J., Granier P., Grappin M., Gueit I., Guihot A., Guillermet C., Guillet-Caruba C., Guimard Y., Hansmann Y., Henquell C., Herrmann J.L., Honnorat J., Houhou N., Jaulhac B., Join-Lambert O., Kossorotoff M., Laudrault E., Laurent F., Laurichesse J.J., Lavoue S., Lazaro L., Legriel S., Lesens O., Level G., Mace M., Maisonneuve B., Makinson A., Marchandin H., Marignier S., Martinez-Almoyna L., Marthelet P., Martinot M., Massenavette B., Maulin L., Mirand A., Misset B., Neuwirth C., Nicot F., Pacanowski J., Palcoux J.B., Pavese P., Perpoint T., Pestel-Caron M., Pouyau R., Prazuck T., Prendki V., Rapp C., Regagnon C., Renie L., Ribadeau-Dumas F., Rigal M., Roch N., Rogeaux O., Rogez S., Santre C., Signori-Schmuck A., Simon F., Taimi A., Tayoro J., Terral D., Therby A., Vuillemet F.
ISSN
1469-4409 (Electronic)
ISSN-L
0950-2688
Publication state
Published
Issued date
02/2012
Peer-reviewed
Oui
Volume
140
Number
2
Pages
372-381
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
This study reports on the clinical profiles of herpes simplex encephalitis (HSE) case-patients and the management of acyclovir prescriptions. We designed a study on the causes of encephalitis in France in 2007. Case-patients fulfilling the inclusion criteria were enrolled in all the hospitals that volunteered to participate. Fifty-five of 253 enrolled case-patients were diagnosed with HSE. Three (5%) HSE patients died and 48 (89%) were discharged with persistent neurological symptoms. All HSE patients were prescribed acyclovir, 10 of whom had a 2-week course; 42 a 3-week course; two received incomplete courses; and one received two courses of 21 days each due to relapse. The acyclovir dosage was reported for 45 adult HSE patients, 25 (53%) of whom received 10 mg/kg t.i.d. and 22 (47%) received 15 mg/kg t.i.d. The mortality rate was low despite 49% of patients being admitted to intensive-care units. A high dose of acyclovir was not associated with a better outcome in HSE patients. Most patients had persisting symptoms on discharge suggesting neuropsychological rehabilitation is an important issue for survivors.
Keywords
Acyclovir/therapeutic use, Adolescent, Aged, Aged, 80 and over, Antiviral Agents/therapeutic use, DNA, Viral/analysis, Encephalitis, Herpes Simplex/cerebrospinal fluid, Encephalitis, Herpes Simplex/diagnosis, Encephalitis, Herpes Simplex/drug therapy, Encephalitis, Herpes Simplex/virology, Encephalitis, Varicella Zoster/diagnosis, Encephalitis, Varicella Zoster/drug therapy, Female, France, Herpesvirus 1, Human/classification, Herpesvirus 1, Human/isolation & purification, Herpesvirus 2, Human/classification, Herpesvirus 2, Human/isolation & purification, Herpesvirus 3, Human/classification, Herpesvirus 3, Human/isolation & purification, Humans, Infant, Newborn, Magnetic Resonance Imaging, Male, Middle Aged, Polymerase Chain Reaction, Prospective Studies, Tomography, X-Ray Computed, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
07/07/2023 11:04
Last modification date
27/02/2024 8:18
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