A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings.

Détails

ID Serval
serval:BIB_A4BE81144959
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings.
Périodique
Cardiovascular Research
Auteur(s)
Pries A.R., Habazettl H., Ambrosio G., Hansen P.R., Kaski J.C., Schächinger V., Tillmanns H., Vassalli G., Tritto I., Weis M., de Wit C., Bugiardini R.
ISSN
0008-6363
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
80
Numéro
2
Pages
165-174
Langue
anglais
Résumé
Obstructive disease of the large coronary arteries is the prominent cause for angina pectoris. However, angina may also occur in the absence of significant coronary atherosclerosis or coronary artery spasm, especially in women. Myocardial ischaemia in these patients is often associated with abnormalities of the coronary microcirculation and may thus represent a manifestation of coronary microvascular disease (CMD). Elucidation of the role of the microvasculature in the genesis of myocardial ischaemia and cardiac damage-in the presence or absence of obstructive coronary atherosclerosis-will certainly result in more rational diagnostic and therapeutic interventions for patients with ischaemic heart disease. Specifically targeted research based on improved assessment modalities is needed to improve the diagnosis of CMD and to translate current molecular, cellular, and physiological knowledge into new therapeutic options.
Mots-clé
Angina Pectoris/etiology, Angina Pectoris/physiopathology, Animals, Coronary Circulation, Coronary Disease/complications, Coronary Disease/diagnosis, Diagnostic Techniques, Cardiovascular, Disease Models, Animal, Endothelium, Vascular/physiopathology, Humans, Microcirculation, Myocardial Ischemia/etiology, Myocardial Ischemia/physiopathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/10/2009 9:02
Dernière modification de la notice
08/05/2019 23:10
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