MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice.

Détails

ID Serval
serval:BIB_A49581FA0C82
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice.
Périodique
NMR in Biomedicine
Auteur(s)
Pialat J.B., Cho T.H., Beuf O., Joye E., Moucharrafie S., Moucharaffie S., Langlois J.B., Nemoz C., Janier M., Berthezene Y., Nighoghossian N., Desvergne B., Wiart M.
ISSN
0952-3480[print], 0952-3480[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
20
Numéro
3
Pages
335-342
Langue
anglais
Résumé
Peroxisome proliferator-activated receptors (PPARs) are a potential target for neuroprotection in focal ischemic stroke. These nuclear receptors have major effects in lipid metabolism, but they are also involved in inflammatory processes. Three PPAR isotypes have been identified: alpha, beta (or delta) and gamma. The development of PPAR transgenic mice offers a promising tool for prospective therapeutic studies. This study used MRI to assess the role of PPARalpha and PPARbeta in the development of stroke. Permanent middle cerebral artery occlusion induced focal ischemia in wild-type, PPARalpha-null mice and PPARbeta-null mice. T(2)-weighted MRI was performed with a 7 T MRI scan on day 0, 1, 3, 7 and 14 to monitor lesion growth in the various genotypes. General Linear Model statistical analysis found a significant difference in lesion volume between wild-type and PPAR-null mice for both alpha and beta isotypes. These data validate high-resolution MRI for monitoring cerebral ischemic lesions, and confirm the neuroprotective role of PPARalpha and PPARbeta in the brain.
Mots-clé
Animals, Brain Edema/pathology, Brain Ischemia/chemically induced, Brain Ischemia/diagnosis, Cerebral Infarction/pathology, Diffusion, Magnetic Resonance Imaging, Male, Mice, Mice, Knockout, PPAR alpha/deficiency, PPAR-beta/deficiency, Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:26
Dernière modification de la notice
08/05/2019 23:09
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