Article: article from journal or magazin.
Kinetics of dexamethasone-induced alterations of glucose metabolism in healthy humans.
American Journal of Physiology. Endocrinology and Metabolism
5 Pt 1
Six healthy human subjects were studied during three 75-g oral, [13C]glucose tolerance tests to assess the kinetics of dexamethasone-induced impairment of glucose tolerance. On one occasion, they received dexamethasone (4 x 0.5 mg/day) during the previous 2 days. On another occasion, they received a single dose (0. 5 mg) of dexamethasone 150 min before ingestion of the glucose load. On the third occasion, they received a placebo. Postload plasma glucose was significantly increased after both 2 days dexamethasone and single dose dexamethasone compared with control (P < 0.05). This corresponded to a 20-23% decrease in the metabolic clearance rate of glucose, whereas total glucose turnover ([6,6-2H]glucose), total (indirect calorimetry) and exogenous glucose oxidation (13CO2 production), and suppression of endogenous glucose production were unaffected by dexamethasone. Plasma insulin concentrations were increased after 2 days of dexamethasone but not after a single dose of dexamethasone. In a second set of experiments, the effect of a single dose of dexamethasone on insulin sensitivity was assessed in six healthy humans during a 2-h euglycemic hyperinsulinemic clamp. Dexamethasone did not significantly alter insulin sensitivity. It is concluded that acute administration of dexamethasone impairs oral glucose tolerance without significantly decreasing insulin sensitivity.
Adult, Blood Glucose/drug effects, Blood Glucose/metabolism, Carbon Dioxide/analysis, Carbon Isotopes, Dexamethasone/pharmacology, Female, Glucose/metabolism, Glucose Clamp Technique, Glucose Tolerance Test, Humans, Infusions, Intravenous, Insulin/administration & dosage, Insulin/blood, Kinetics, Male, Reference Values, Time Factors
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