Different effects of angiotensin-converting enzyme inhibition in human arteries and veins

Détails

ID Serval
serval:BIB_A482B10D3DD6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Different effects of angiotensin-converting enzyme inhibition in human arteries and veins
Périodique
Journal of Cardiovascular Pharmacology
Auteur(s)
Yang  Z., Arnet  U., von Segesser  L., Siebenmann  R., Turina  M., Luscher  T. F.
ISSN
0160-2446
Statut éditorial
Publié
Date de publication
1993
Peer-reviewed
Oui
Volume
22 Suppl 5
Pages
S17-22
Notes
Comparative Study
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Résumé
The renin-angiotensin system (RAS) participates in the regulation of vascular tone; its effects were studied in human internal mammary artery (IMA) and saphenous vein (SV) suspended in organ chambers for isometric tension recording. The angiotensin-converting enzyme (ACE) inhibitor enalaprilat (10(-7) M) markedly augmented endothelium-dependent relaxations to bradykinin in SV (concentration shift: 10-fold; n = 6; p < 0.005), but not in IMA; in both blood vessels, it had no effect on endothelium-dependent relaxations to acetylcholine. The contractions to angiotensin I (Ang I; 10(-7) M) were markedly inhibited by enalaprilat (10(-7) M) in SV (control: 34 +/- 6% of 100 mM KCl; treatment: 18 +/- 6%; n = 7; p < 0.05) but not in IMA (control: 33 +/- 4%; treatment: 30 +/- 6%; n = 7; NS) and abolished by the Ang II receptor antagonist DuP 753 (10(-7) M) in both blood vessels. Ang II (10(-7) M) induced more pronounced contractions than Ang I in IMA (63 +/- 4%) and SV (63 +/- 5%; n = 5-6; p < 0.05 vs. Ang I), which was markedly inhibited by DuP 753 (10(-7) M; IMA: 21 +/- 5%; SV: 32 +/- 5%; p < 0.05). Thus, in SV but not IMA, ACE inactivates bradykinin and thereby blunts endothelium-dependent relaxations to the peptide and converts Ang I to Ang II.
Mots-clé
Acetylcholine/pharmacology Angiotensin I/pharmacology Angiotensin II/antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors/*pharmacology Biphenyl Compounds/pharmacology Bradykinin/pharmacology Enalaprilat/*pharmacology Endothelium, Vascular/drug effects/physiology Humans Imidazoles/pharmacology Losartan Mammary Arteries/*drug effects/physiology Muscle Contraction/drug effects Muscle Relaxation/drug effects Muscle, Smooth, Vascular/*drug effects/physiology Norepinephrine/pharmacology Saphenous Vein/*drug effects/physiology Tetrazoles/pharmacology
Pubmed
Web of science
Création de la notice
14/02/2008 15:19
Dernière modification de la notice
03/03/2018 20:13
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