Jonctions communicantes et sécrétion [Gap junctions and secretion]

Détails

ID Serval
serval:BIB_A46A7300E1E3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Jonctions communicantes et sécrétion [Gap junctions and secretion]
Périodique
Revue médicale suisse
Auteur(s)
Haefliger J.A., Allagnat F., Krattinger N., Martin D., Waeber G., Nicod P., Meda P.
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2005
Volume
1
Numéro
17
Pages
1134-9
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review - Publication Status: ppublish
Résumé
The emergence of multicellular organisms has necessitated the development of mechanisms for interactions between adjacent and distant cells. A consistent feature of this network is the expression of gap junction channels between the secretory cells of all glands so far investigated in vertebrates. Here, we reviewed the distribution of the gap junctions proteins, named connexins, in a few mammalian glands, and discussed the recent evidence pointing to the participation of these proteins in the functioning of endocrine and exocrine cells. Specifically, available data indicate the importance of gap junctions for the proper control of glucose-induced insulin secretion. Understanding the functions of beta-cell connexins are crucial for the engineering of surrogate cells, which is necessary for implementation of a replacement cell therapy in diabetic patients.
Mots-clé
Animals, Connexins, Endocrine System, Gap Junctions, Humans, Islets of Langerhans
Pubmed
Création de la notice
25/01/2008 14:48
Dernière modification de la notice
20/08/2019 16:09
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